Cryptosporidium parvum-induced ileo-caecal ...
Type de document :
Article dans une revue scientifique
DOI :
PMID :
URL permanente :
Titre :
Cryptosporidium parvum-induced ileo-caecal adenocarcinoma and Wnt signaling in a mouse model
Auteur(s) :
Benamrouz, Sadia [Auteur]
Conseil, Valerie [Auteur]
Chabé, Magali [Auteur]
Praet, Marleen [Auteur]
Audebert, Christophe [Auteur]
Blervaque, Renaud [Auteur]
Guyot, Karine [Auteur]
Gazzola, Sophie [Auteur]
Mouray, Anthony [Auteur]
Chassat, Thierry [Auteur]
Delaire, Baptiste [Auteur]
Goetinck, Nathalie [Auteur]
Gantois, Nausicaa [Auteur]
Osman, Marwan [Auteur]
Slomianny, Christian [Auteur]
Dehennaut, Vanessa [Auteur]
Lefebvre, Tony [Auteur]
Viscogliosi, Eric [Auteur]
Cuvelier, Claude [Auteur]
Dei-Cas, Eduardo [Auteur]
Creusy, Colette [Auteur]
Certad, Gabriela [Auteur]
Conseil, Valerie [Auteur]
Chabé, Magali [Auteur]
Praet, Marleen [Auteur]
Audebert, Christophe [Auteur]
Blervaque, Renaud [Auteur]
Guyot, Karine [Auteur]
Gazzola, Sophie [Auteur]
Mouray, Anthony [Auteur]
Chassat, Thierry [Auteur]
Delaire, Baptiste [Auteur]
Goetinck, Nathalie [Auteur]
Gantois, Nausicaa [Auteur]
Osman, Marwan [Auteur]
Slomianny, Christian [Auteur]
Dehennaut, Vanessa [Auteur]
Lefebvre, Tony [Auteur]
Viscogliosi, Eric [Auteur]
Cuvelier, Claude [Auteur]
Dei-Cas, Eduardo [Auteur]
Creusy, Colette [Auteur]
Certad, Gabriela [Auteur]
Titre de la revue :
Disease Models & Mechanisms
Nom court de la revue :
Dis Model Mech
Numéro :
7
Pagination :
693-700
Date de publication :
2014-06
ISSN :
1754-8411
Mot(s)-clé(s) en anglais :
Adenocarcinoma
Signal Transduction
beta Catenin
Wnt pathway
Wnt Proteins
Cryptosporidiosis
Digestive cancer
Genes, p53
Animals
Cryptosporidium parvum
Cadherins
Cytoskeleton
Mice
SCID mouse model
Genes, ras
Intestinal Neoplasms
Disease Models, Animal
Signal Transduction
beta Catenin
Wnt pathway
Wnt Proteins
Cryptosporidiosis
Digestive cancer
Genes, p53
Animals
Cryptosporidium parvum
Cadherins
Cytoskeleton
Mice
SCID mouse model
Genes, ras
Intestinal Neoplasms
Disease Models, Animal
Discipline(s) HAL :
Chimie/Chimie théorique et/ou physique
Résumé en anglais : [en]
Cryptosporidium species are apicomplexan protozoans that are found worldwide. These parasites constitute a large risk to human and animal health. They cause self-limited diarrhea in immunocompetent hosts and a life-threatening ...
Lire la suite >Cryptosporidium species are apicomplexan protozoans that are found worldwide. These parasites constitute a large risk to human and animal health. They cause self-limited diarrhea in immunocompetent hosts and a life-threatening disease in immunocompromised hosts. Interestingly, Cryptosporidium parvum has been related to digestive carcinogenesis in humans. Consistent with a potential tumorigenic role of this parasite, in an original reproducible animal model of chronic cryptosporidiosis based on dexamethasone-treated or untreated adult SCID mice, we formerly reported that C. parvum (strains of animal and human origin) is able to induce digestive adenocarcinoma even in infections induced with very low inoculum. The aim of this study was to further characterize this animal model and to explore metabolic pathways potentially involved in the development of C. parvum-induced ileo-caecal oncogenesis. We searched for alterations in genes or proteins commonly involved in cell cycle, differentiation or cell migration, such as β-catenin, Apc, E-cadherin, Kras and p53. After infection of animals with C. parvum we demonstrated immunohistochemical abnormal localization of Wnt signaling pathway components and p53. Mutations in the selected loci of studied genes were not found after high-throughput sequencing. Furthermore, alterations in the ultrastructure of adherens junctions of the ileo-caecal neoplastic epithelia of C. parvum-infected mice were recorded using transmission electron microscopy. In conclusion, we found for the first time that the Wnt signaling pathway, and particularly the cytoskeleton network, seems to be pivotal for the development of the C. parvum-induced neoplastic process and cell migration of transformed cells. Furthermore, this model is a valuable tool in understanding the host-pathogen interactions associated with the intricate infection process of this parasite, which is able to modulate host cytoskeleton activities and several host-cell biological processes and remains a significant cause of infection worldwide.Lire moins >
Lire la suite >Cryptosporidium species are apicomplexan protozoans that are found worldwide. These parasites constitute a large risk to human and animal health. They cause self-limited diarrhea in immunocompetent hosts and a life-threatening disease in immunocompromised hosts. Interestingly, Cryptosporidium parvum has been related to digestive carcinogenesis in humans. Consistent with a potential tumorigenic role of this parasite, in an original reproducible animal model of chronic cryptosporidiosis based on dexamethasone-treated or untreated adult SCID mice, we formerly reported that C. parvum (strains of animal and human origin) is able to induce digestive adenocarcinoma even in infections induced with very low inoculum. The aim of this study was to further characterize this animal model and to explore metabolic pathways potentially involved in the development of C. parvum-induced ileo-caecal oncogenesis. We searched for alterations in genes or proteins commonly involved in cell cycle, differentiation or cell migration, such as β-catenin, Apc, E-cadherin, Kras and p53. After infection of animals with C. parvum we demonstrated immunohistochemical abnormal localization of Wnt signaling pathway components and p53. Mutations in the selected loci of studied genes were not found after high-throughput sequencing. Furthermore, alterations in the ultrastructure of adherens junctions of the ileo-caecal neoplastic epithelia of C. parvum-infected mice were recorded using transmission electron microscopy. In conclusion, we found for the first time that the Wnt signaling pathway, and particularly the cytoskeleton network, seems to be pivotal for the development of the C. parvum-induced neoplastic process and cell migration of transformed cells. Furthermore, this model is a valuable tool in understanding the host-pathogen interactions associated with the intricate infection process of this parasite, which is able to modulate host cytoskeleton activities and several host-cell biological processes and remains a significant cause of infection worldwide.Lire moins >
Langue :
Anglais
Établissement(s) :
CHU Lille
CNRS
Inserm
Université de Lille
Institut Pasteur de Lille
CNRS
Inserm
Université de Lille
Institut Pasteur de Lille
Collections :
Équipe(s) de recherche :
O-GlcNAcylation, signalisation cellulaire et cycle cellulaire
Date de dépôt :
2020-02-12T15:11:49Z