Sialic Acid and Cancer
Document type :
Partie d'ouvrage: Chapitre
Permalink :
Title :
Sialic Acid and Cancer
Author(s) :
Julien, Sylvain [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Delannoy, Philippe [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Delannoy, Philippe [Auteur]

Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Scientific editor(s) :
Taniguchi, Naoyuki
Endo, Tamao
Hart, Gerald W.
Seeberger, Peter H.
Wong, Chi-Huey
Endo, Tamao
Hart, Gerald W.
Seeberger, Peter H.
Wong, Chi-Huey
Book title :
Glycoscience : biology and medecine
Pages :
1419-1424
Publisher :
Springer Japan
Publication place :
Tokyo
Publication date :
2015
ISBN :
978-4-431-54840-9, 978-4-431-54841-6
English keyword(s) :
Sialic acid
Tumor associated carbohydrate antigen
O-glycan
Ganglioside
Anticancer vaccine
Tumor associated carbohydrate antigen
O-glycan
Ganglioside
Anticancer vaccine
HAL domain(s) :
Chimie/Chimie théorique et/ou physique
English abstract : [en]
Sialic acids are nine-carbon acidic monosaccharides found in terminal position of glycan chains. The sialylation of cell surface glycoconjugates is frequently altered in cancers, resulting in the expression of sialylated ...
Show more >Sialic acids are nine-carbon acidic monosaccharides found in terminal position of glycan chains. The sialylation of cell surface glycoconjugates is frequently altered in cancers, resulting in the expression of sialylated tumor-associated carbohydrate antigens that are specific markers for this disease. Because sialylated glycans are involved in many biological processes, their expression by tumor cells is often associated with increased aggressiveness and metastatic potential of the tumors. The sialylated tumor-associated carbohydrate antigens are usually weakly expressed by healthy tissues and can be therefore used as immunotherapeutic targets for anticancer vaccines. This chapter summarizes the main tumor-associated sialylated structures and their role in cancer cells biology as well as their use for the development of anticancer vaccines.Show less >
Show more >Sialic acids are nine-carbon acidic monosaccharides found in terminal position of glycan chains. The sialylation of cell surface glycoconjugates is frequently altered in cancers, resulting in the expression of sialylated tumor-associated carbohydrate antigens that are specific markers for this disease. Because sialylated glycans are involved in many biological processes, their expression by tumor cells is often associated with increased aggressiveness and metastatic potential of the tumors. The sialylated tumor-associated carbohydrate antigens are usually weakly expressed by healthy tissues and can be therefore used as immunotherapeutic targets for anticancer vaccines. This chapter summarizes the main tumor-associated sialylated structures and their role in cancer cells biology as well as their use for the development of anticancer vaccines.Show less >
Language :
Anglais
Audience :
Non spécifiée
Administrative institution(s) :
CNRS
Université de Lille
Université de Lille
Research team(s) :
Régulation de la glycosylation terminale
Submission date :
2020-02-12T15:44:44Z
2021-04-23T06:31:13Z
2021-04-23T06:31:13Z