Titre :

Norine: update of the nonribosomal peptide resource

Auteur(s) :

Flissi, Areski [Auteur]
Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 [CRIStAL]
Ricart, Emma [Auteur]
Université de Genève = University of Geneva [UNIGE]
Swiss Institute of Bioinformatics [Genève] [SIB]
Campart, Clémentine [Auteur]
Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 [CRIStAL]
Chevalier, Mickael [Auteur]
Institut Charles Viollette (ICV) - ULR 7394 [ICV]
Dufresne, Yoann [Auteur]
Département de Biologie Computationnelle - Department of Computational Biology
Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 [CRIStAL]
Michalik, Juraj [Auteur]
Plateforme de bioinformatique et de biostatistique de Lille - PLBS [Bilille]
Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 [CRIStAL]
Jacques, Philippe [Auteur]
Flahaut, Christophe [Auteur]
Institut Charles Viollette (ICV) - ULR 7394 [ICV]
Lisacek, Frederique [Auteur]
Université de Genève = University of Geneva [UNIGE]
Swiss Institute of Bioinformatics [Genève] [SIB]
Leclere, Valerie [Auteur]
Institut Charles Viollette (ICV) - ULR 7394 [ICV]
Pupin, Maude [Auteur]
Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 [CRIStAL]

Titre de la revue :

Nucleic acids research

Éditeur :

Oxford University Press

Date de publication :

2019

ISSN :

0305-1048

Discipline(s) HAL :

Sciences du Vivant [q-bio]
Informatique [cs]

Résumé en anglais : [en]

Norine, the unique resource dedicated to nonribo-somal peptides (NRPs), is now updated with a new pipeline to automate massive sourcing and enhance annotation. External databases are mined to extract NRPs that are not yet ...
Lire la suite >Norine, the unique resource dedicated to nonribo-somal peptides (NRPs), is now updated with a new pipeline to automate massive sourcing and enhance annotation. External databases are mined to extract NRPs that are not yet in Norine. To maintain a high data quality, successive filters are applied to automatically validate the NRP annotations and only validated data is inserted in the database. External databases were also used to complete annotations of NRPs already in Norine. Besides, annotation consistency inside Norine and between Norine and external sources have reported annotation errors. Some can be corrected automatically, while others need manual curation. This new approach led to the insertion of 539 new NRPs and the addition or correction of annotations of nearly all Norine entries. Two new tools to analyse the chemical structures of NRPs (rBAN) and to infer a molecular formula from the mass-to-charge ratio of an NRP (Kendrick Formula Predictor) were also integrated. Norine is freely accessible from the following URL: https://bioinfo.cristal.univ-lille.fr/ norine/Lire moins >

Langue :

Anglais

Comité de lecture :

Oui

Audience :

Internationale

Vulgarisation :

Non

Projet ANR :

Institut français de bioinformatique

Collections :

• Centre de Recherche en Informatique, Signal et Automatique de Lille (CRIStAL) - UMR 9189

Source :

Harvested from HAL