Mechanisms of coronavirus cell entry mediated by the viral spike protein

Belouzard, Sandrine; Millet, Jean; Licitra, Beth N.; Whittaker, Gary R.

Type de document :

Article dans une revue scientifique: Article de synthèse/Review paper

DOI :

10.3390/v4061011

PMID :

22816037

Titre :

Mechanisms of coronavirus cell entry mediated by the viral spike protein

Auteur(s) :

Belouzard, Sandrine [Auteur]
Université Lille Nord de France (COMUE)
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Millet, Jean [Auteur]
Licitra, Beth N. [Auteur]
Whittaker, Gary R. [Auteur]

Titre de la revue :

Viruses

Pagination :

1011-1033

Éditeur :

MDPI

Date de publication :

2012

ISSN :

1999-4915

Mot(s)-clé(s) en anglais :

coronavirus
spike
viral entry
fusion
proteolytic activation

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Coronaviruses are enveloped positive-stranded RNA viruses that replicate in the cytoplasm. To deliver their nucleocapsid into the host cell, they rely on the fusion of their envelope with the host cell membrane. The spike ...
Lire la suite >Coronaviruses are enveloped positive-stranded RNA viruses that replicate in the cytoplasm. To deliver their nucleocapsid into the host cell, they rely on the fusion of their envelope with the host cell membrane. The spike glycoprotein (S) mediates virus entry and is a primary determinant of cell tropism and pathogenesis. It is classified as a class I fusion protein, and is responsible for binding to the receptor on the host cell as well as mediating the fusion of host and viral membranes-A process driven by major conformational changes of the S protein. This review discusses coronavirus entry mechanisms focusing on the different triggers used by coronaviruses to initiate the conformational change of the S protein: receptor binding, low pH exposure and proteolytic activation. We also highlight commonalities between coronavirus S proteins and other class I viral fusion proteins, as well as distinctive features that confer distinct tropism, pathogenicity and host interspecies transmission characteristics to coronaviruses.Lire moins >

Langue :

Anglais

Comité de lecture :

Oui

Audience :

Internationale

Vulgarisation :

Non

Collections :

Centre d'Infection et d'Immunité de Lille (CIIL) - U1019 - UMR 9017

Source :

Harvested from HAL

Fichiers

https://hal.inrae.fr/hal-02652528/document
Accès libre
Accéder au document

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397359
Accès libre
Accéder au document

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397359
Accès libre
Accéder au document

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397359
Accès libre
Accéder au document

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397359
Accès libre
Accéder au document

document
Accès libre
Accéder au document

2012_Belouzard_Viruses_1.pdf
Accès libre
Accéder au document

PMC3397359
Accès libre
Accéder au document

document
Accès libre
Accéder au document

2012_Belouzard_Viruses_1.pdf
Accès libre
Accéder au document

Mechanisms of coronavirus cell entry ... BibTeX CSV Excel RIS

Fichiers

Mechanisms of coronavirus cell entry ...

BibTeX

CSV

Excel

RIS