Title :

How motility can enhance mass transfer and absorption in the duodenum: Taking the structure of the villi into account

Author(s) :

Zhang, Yanan [Auteur]
Wu, Peng [Auteur]
Jeantet, Romain [Auteur]
Dupont, Didier [Auteur]
Delaplace, Guillaume [Auteur]
Unité Matériaux et Transformations (UMET) - UMR 8207
Unité Matériaux et Transformations - UMR 8207 [UMET]
Chen, Xiao Dong [Auteur]
Xiao, Jie [Auteur]

Journal title :

Chemical Engineering Science

Volume number :

213

Pages :

115406

Publisher :

Elsevier BV

Publication date :

2020-02-23

ISSN :

0009-2509

English keyword(s) :

Motility
Small intestine
Villi
Mass transfer and absorption
Numerical simulation
Moving mesh method

HAL domain(s) :

Sciences du Vivant [q-bio]/Ingénierie des aliments

English abstract : [en]

Given the complex motility of the intestinal wall featuring villous structure, the mechanisms by which the motility can enhance mass transfer and absorption in the small intestine have been a mystery. In this work, the ...
Show more >Given the complex motility of the intestinal wall featuring villous structure, the mechanisms by which the motility can enhance mass transfer and absorption in the small intestine have been a mystery. In this work, the challenging task to couple the intestinal lumen flow and the contraction movement of the villi is tackled by a multi-physics model. The effects of motility of an entire duodenum on the mass transfer and absorption under the influence of ambient flow can be systematically explored. It is revealed that the top of the villi plays a major role in mass absorption. For a rat duodenum, the pendular movement can enhance mass transfer and absorption by up to about 72%. With the introduction of ambient flow, although the absorption amount increases, the enhancement of mass transfer by pendular activity is inhibited. Specifically, the average enhancement factor decreases sharply from ~1.35 to ~1.05.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CNRS
INRA
ENSCL

Collections :

• Unité Matériaux et Transformations (UMET) - UMR 8207

Research team(s) :

Processus aux Interfaces et Hygiène des Matériaux (PIHM)

Submission date :

2020-12-04T14:09:44Z