Title :

Definition of the Anti-inflammatory Oligosaccharides Derived From the Galactosaminogalactan (GAG) From Aspergillus fumigatus

Author(s) :

Gressler, Markus [Auteur]
Aspergillus
Heddergott, Christoph [Auteur]
Aspergillus
N'Go, Inés C. [Auteur]

Renga, Giorgia [Auteur]
Università degli Studi di Perugia = University of Perugia [UNIPG]
Oikonomou, Vasilis [Auteur]
Università degli Studi di Perugia = University of Perugia [UNIPG]
Moretti, Silvia [Auteur]
Università degli Studi di Perugia = University of Perugia [UNIPG]
Coddeville, Bernadette [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Gaifem, Joana [Auteur]
Life and Health Sciences Research Institute [Braga] [ICVS]
Silvestre, Ricardo [Auteur]
Life and Health Sciences Research Institute [Braga] [ICVS]
Romani, Luigina [Auteur]
Università degli Studi di Perugia = University of Perugia [UNIPG]
Latgé, Jean-Paul [Auteur]

Fontaine, Thierry [Auteur]
Aspergillus

Journal title :

Frontiers in Cellular and Infection Microbiology

Abbreviated title :

Front. Cell. Infect. Microbiol.

Volume number :

9

Publisher :

Frontiers Media SA

Publication date :

2019-11-06

ISSN :

2235-2988

English keyword(s) :

galactosaminogalactan
Aspergillus fumigatus
IL-Ra
anti-inflammatory response
glycodrug

HAL domain(s) :

Sciences du Vivant [q-bio]
Chimie/Chimie théorique et/ou physique

English abstract : [en]

Galactosaminogalactan (GAG) is an insoluble aminosugar polymer produced byAspergillus fumigatusand has anti-inflammatory properties. Here, the minimumglycosidic sequences required for the induction of IL-1Ra by peripheral ...
Show more >Galactosaminogalactan (GAG) is an insoluble aminosugar polymer produced byAspergillus fumigatusand has anti-inflammatory properties. Here, the minimumglycosidic sequences required for the induction of IL-1Ra by peripheral bloodmononuclear cells (PBMCs) was investigated. Using chemical degradation of native GAGto isolate soluble oligomers, we have found that the de-N-acetylation of galactosamineresidues and the size of oligomer are critical for thein vitroimmune response. A minimaloligomer size of 20 galactosamine residues is required for the anti-inflammatory responsebut the presence of galactose residues is not necessary. In aDextran sulfate inducedcolitis mouse model, a fraction of de-N-acetylated oligomers of 13<dp<20 rescueinflammatory damage like the native GAG polymer in an IL-1Ra dependent pathway. Ourresults demonstrate the therapeutic suitability of water-soluble GAG oligosaccharidesin IL-1 mediated hyper-inflammatory diseases and suggest thatα-1,4-galactosamineoligomers chemically synthesized could represent new anti-inflammatory glycodrugs.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CNRS

Collections :

• Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576

Research team(s) :

Chemical Glycobiology

Submission date :

2020-12-07T12:35:58Z
2020-12-07T16:55:16Z