Titre :

Developing a MEMS device for high-throughput multi-parameter single cell biophysical analysis

Auteur(s) :

Rezard, Quentin [Auteur]
Laboratory for Integrated Micro Mechatronics Systems [LIMMS]
Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 [IEMN]
Perret, Gregoire [Auteur]
Laboratory for Integrated Micro Mechatronics Systems [LIMMS]
Gerbedoen, Jean Claude [Auteur]
Laboratory for Integrated Micro Mechatronics Systems [LIMMS]
Pekin, Deniz [Auteur]
Laboratory for Integrated Micro Mechatronics Systems [LIMMS]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Cleri, Fabrizio [Auteur]
Physique - IEMN [PHYSIQUE - IEMN]
Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 [IEMN]
Collard, Dominique [Auteur]
Laboratory for Integrated Micro Mechatronics Systems [LIMMS]
Lagadec (Admin), Chann [Auteur]
Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers = Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 [CANTHER]
Tarhan, Mehmet-Cagatay [Auteur correspondant]
Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 [IEMN]

Titre de la manifestation scientifique :

2021 IEEE 34th International Conference on Micro Electro Mechanical Systems, MEMS 2021

Ville :

Gainesville (on line)

Pays :

Etats-Unis d'Amérique

Date de début de la manifestation scientifique :

2021-01-25

Titre de la revue :

Proceedings of the IEEE 34th International Conference on Micro Electro Mechanical Systems, MEMS 2021

Éditeur :

IEEE

Mot(s)-clé(s) en anglais :

Biophysical cell characterization
high-throughput measurements
single-cell analysis
cancer

Discipline(s) HAL :

Sciences de l'ingénieur [physics]
Physique [physics]

Résumé en anglais : [en]

We introduced a MEMS device to perform direct measurements on electrical and mechanical properties of single cancer cells. Working in a continuous flow format permits high-throughput measurements. The device design allows ...
Lire la suite >We introduced a MEMS device to perform direct measurements on electrical and mechanical properties of single cancer cells. Working in a continuous flow format permits high-throughput measurements. The device design allows us to define fixed or movable electrodes as part of the side-walls of an embedded microchannel. The stable air-liquid interface at micro-sized gaps between the electrodes and the channel wall provide flow continuity without causing any leakage problems. This unified processing approach allows us to define optimized electrode pattern configuration for both electrical and mechanical characterization areas. Moreover, the movable electrode is in direct contact with passing cells which enables direct sensing during compression. The device can perform both electrical and mechanical measurements on single cells in a continuous flow as demonstrated and also validated by optical control measurements. The proposed method aims at providing high-throughput biophysical cytometry, in an optics- and marker-free way, for cancer cell evaluation.Lire moins >

Langue :

Anglais

Comité de lecture :

Oui

Audience :

Internationale

Vulgarisation :

Non

Collections :

• Cancer Heterogeneity, Plasticity and Resistance to Therapies (CANTHER) - UMR 9020 - UMR 1277

Source :

Harvested from HAL