Hindlimb unloading affects cortical motor maps and decreases corticospinal excitability

Langlet, Cécile; Bastide, Bruno; Canu, Marie-Hélène

Type de document :

Article dans une revue scientifique

DOI :

10.1016/j.expneurol.2012.06.018

URL permanente :

http://hdl.handle.net/20.500.12210/39352

Titre :

Hindlimb unloading affects cortical motor maps and decreases corticospinal excitability

Auteur(s) :

Langlet, Cécile [Auteur]
Laboratoire d'automatique humaine et sciences comportementales [LASC]
Bastide, Bruno [Auteur]

Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369 - ULR 4488 [URePSSS]
Canu, Marie-Hélène [Auteur]
Activité Physique, Muscle, Santé [EA4488]

Titre de la revue :

Experimental Neurology

Nom court de la revue :

Experimental Neurology

Numéro :

237

Pagination :

211-217

Éditeur :

Elsevier BV

Date de publication :

2012-09

ISSN :

0014-4886

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

A chronic reduction in neuromuscular activity through prolonged body immobilization of humans results in muscle atrophy and weakness as well as motor tasks performance impairment, which is correlated to a change in ...
Lire la suite >A chronic reduction in neuromuscular activity through prolonged body immobilization of humans results in muscle atrophy and weakness as well as motor tasks performance impairment, which is correlated to a change in corticospinal excitability. In rats, hindlimb unloading (HU) is commonly used to mimic the effects of confinement to bed in patients. Several studies have reported changes in the representation of the somatosensory cortex in rodents submitted to HU or sensorimotor restriction by casting: remapping and enlargement of receptive fields, changes in the response of layer 4 neurons to peripheral stimulation. However, we have no data about motor cortical maps in rats submitted to a period of motor restriction during adulthood. Therefore, the objectives of the present study were twofold: to determine, in control rats and in rats submitted to a 14-day period of HU, the size and organization of hindlimb representation in the M1 cortex and to evaluate the overall excitability of M1 cortex by determining the stimulation thresholds. HU led to a dramatic decrease in the hindlimb representation on the M1 cortex (− 61%, p < 0.01). In addition, current thresholds for eliciting a movement were increased. The toes were less strongly affected by HU than other joint. Our main conclusion is that HU dramatically affects the organization and functioning of cortical motor maps and decreases corticospinal excitability.Lire moins >

Langue :

Anglais

Audience :

Non spécifiée

Établissement(s) :

Université de Lille
Univ. Artois
Univ. Littoral Côte d’Opale

Collections :

Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369

Date de dépôt :

2021-05-17T11:45:21Z
2021-05-17T12:47:41Z
2021-05-17T12:49:48Z
2022-02-09T08:55:14Z

Fichiers

YEXNR11182.pdf
Version éditeur
Accès confidentiel
Accéder au document

Historique des modifications

Numéro de version	Lien	Date de modification
4	20.500.12210/39352*	2022-02-09T08:53:41Z
3	20.500.12210/39352.3	2021-05-17T12:48:43Z
2	20.500.12210/39352.2	2021-05-17T12:44:43Z
1	20.500.12210/39352.1	2021-05-17T11:45:21Z

*Version sélectionnée

Hindlimb unloading affects cortical motor ... BibTeX CSV Excel RIS

Fichiers

Historique des modifications

Hindlimb unloading affects cortical motor ...

BibTeX

CSV

Excel

RIS