MDPV and α-PVP use in humans: The twisted sisters

Karila, Laurent; Lafaye, Geneviève; Scocard, Amandine; Cottencin, Olivier; Benyamina, Amine

Document type :

Article dans une revue scientifique

DOI :

10.1016/j.neuropharm.2017.10.007

PMID :

29030166

Permalink :

http://hdl.handle.net/20.500.12210/3971

Title :

MDPV and α-PVP use in humans: The twisted sisters

Author(s) :

Karila, Laurent [Auteur]
Neuroimagerie en psychiatrie [U1000]
Lafaye, Geneviève [Auteur]
Scocard, Amandine [Auteur]
Université de Bordeaux [UB]
Cottencin, Olivier [Auteur]

Laboratoire Sciences Cognitives et Sciences Affectives - UMR 9193 [SCALab]
Benyamina, Amine [Auteur]
Hôpital Paul Brousse

Journal title :

Neuropharmacology

Abbreviated title :

Neuropharmacology

Volume number :

134

Pages :

65-72

Publication date :

2017-10-10

ISSN :

1873-7064

HAL domain(s) :

Sciences cognitives

English abstract : [en]

The new psychoactive substances phenomenon continues to represent a considerable public health challenge. Synthetic cathinones are β-keto amphetamine analogues, also known as legal highs, research chemicals, bath salts. ...
Show more >The new psychoactive substances phenomenon continues to represent a considerable public health challenge. Synthetic cathinones are β-keto amphetamine analogues, also known as legal highs, research chemicals, bath salts. These drugs have surfaced as a popular alternative to other illicit drugs of abuse, such as cocaine, MDMA, and methamphetamine, due to their potent psychostimulant and empathogenic effects. Pyrovalerone cathinones (a-pyrrolidinophenones) form a distinct group of designer cathinones, such as MDPV. After being listed as an illegal product, "second generation" compounds such as α-PVP, sharing a very similar chemical structure with MDPV, were developed. Clinical effects of these compounds are individual, dose- and route of administration-dependent. Both of them have been involved in an increased number of, not only acute intoxications but also fatalities over the past few years, raising concerns in the medical field. In this paper, we will review the available data regarding the use and effects of MDPV and α-PVP in humans in order to highlight their impact on public health. Health actors and general population need to be clearly informed of potential risks and consequences of these 2 novel psychoactive substances spread and use. The literature search conducted led to the identification of potentially 83 relevant articles. All articles were screened from their abstracts to determine their relevance in the framework of the current review.Show less >

Language :

Anglais

Audience :

Non spécifiée

Administrative institution(s) :

Université de Lille
CNRS
CHU Lille

Collections :

Sciences Cognitives et Sciences Affectives (SCALab) - UMR 9193

Research team(s) :

Équipe Psychiatrie & Croyance (PsyCHIC)

Submission date :

2019-02-13T14:17:48Z
2020-04-03T08:25:16Z

Version	Link	Modification date
2	20.500.12210/3971*	2020-04-03T08:19:32Z
1	20.500.12210/3971.1	2019-02-13T14:17:48Z

MDPV and α-PVP use in humans: The twisted sisters

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MDPV and α-PVP use in humans: The twisted sisters

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