Title :

Progressive multifocal leukoencephalopathy: mri findings in hiv-infected patients are closer to rituximab- than natalizumab-associated pml

Author(s) :

Alleg, Manel [Auteur]
Solis, Morgane [Auteur]
Baloglu, Seyyid [Auteur]
Cotton, Francois [Auteur]
Université Claude Bernard Lyon 1 [UCBL]
Kerschen, Philippe [Auteur]
Bourre, Bertrand [Auteur]
Ahle, Guido [Auteur]
Pruvo, Jean-Pierre [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Leclerc, Xavier [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Vermersch, Patrick [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Papeix, Caroline [Auteur]
Maillart, Elisabeth [Auteur]
Houillier, Caroline [Auteur]
Sorbonne Université [SU]
Chabrot, Cecile Molucon [Auteur]
Claise, Beatrice [Auteur]
Malak, Sandra [Auteur]
Martin-Blondel, Guillaume [Auteur]
Centre de Physiopathologie Toulouse Purpan [CPTP]
Bonneville, Fabrice [Auteur]
Caulier, Alexis [Auteur]
Marolleau, Jean-Pierre [Auteur]
Bonnefoy, Jerome Tamburini [Auteur]
Agape, Philippe [Auteur]
Kennel, Celine [Auteur]
Roussel, Xavier [Auteur]
Chauchet, Adrien [Auteur]
De Seze, Jerome [Auteur]
Fafi-Kremer, Samira [Auteur]
Kremer, Stephane [Auteur]

Journal title :

European Radiology

Abbreviated title :

Eur Radiol

Publication date :

2021-05

ISSN :

1432-1084

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Objectives To compare brain MRI findings in progressive multifocal leukoencephalopathy (PML) associated to rituximab and natalizumab treatments and HIV infection. Materials and methods In this retrospective, multicentric ...
Show more >Objectives To compare brain MRI findings in progressive multifocal leukoencephalopathy (PML) associated to rituximab and natalizumab treatments and HIV infection. Materials and methods In this retrospective, multicentric study, we analyzed brain MRI exams from 72 patients diagnosed with definite PML: 32 after natalizumab treatment, 20 after rituximab treatment, and 20 HIV patients. We compared T2- or FLAIR-weighted images, diffusion-weighted images, T2*-weighted images, and contrast enhancement features, as well as lesion distribution, especially gray matter involvement. Results The three PML entities affect U-fibers associated with low signal intensities on T2*-weighted sequences. Natalizumab-associated PML showed a punctuate microcystic appearance in or in the vicinity of the main PML lesions, a potential involvement of the cortex, and contrast enhancement. HIV and rituximab-associated PML showed only mild contrast enhancement, punctuate appearance, and cortical involvement. The CD4/CD8 ratio showed a trend to be higher in the natalizumab group, possibly mirroring a more efficient immune response. Conclusion Imaging features of rituximab-associated PML are different from those of natalizumab-associated PML and are closer to those observed in HIV-associated PML.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
CNRS
Inserm
Université de Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Research team(s) :

Neuroinflammation & Multiple Sclerosis (NEMESIS)
Troubles cognitifs dégénératifs et vasculaires

Submission date :

2021-06-23T11:40:41Z
2024-02-19T13:50:06Z