Titre :

Trajectory of serum bilirubin predicts spontaneous recovery in a real-world cohort of patients with alcoholic hepatitis

Auteur(s) :

Parker, Richard [Auteur]
Cabezas, Joaquin [Auteur]
Altamirano, Jose [Auteur]
Arab, Juan Pablo [Auteur]
Ventura-Cots, Meritxell [Auteur]
Sinha, Ashish [Auteur]
Dhanda, Ashwin [Auteur]
Arrese, Marco [Auteur]
Mccune, C. Anne [Auteur]
Rowe, Ian A. [Auteur]
Schnabl, Bernd [Auteur]
Mathurin, Philippe [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Shawcross, Debbie L. [Auteur]
Abraldes, Juan G. [Auteur]
Lucey, Michael R. [Auteur]
Garcia-Tsao, Guadalupe [Auteur]
Verna, Elizabeth C. [Auteur]
Brown, Robert S. [Auteur]
Bosques-Padilla, Francisco [Auteur]
Vargas, Victor [Auteur]
Louvet, Alexandre [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Holt, Andrew P. [Auteur]
Bataller, Ramon [Auteur]

Titre de la revue :

Clinical Gastroenterology and Hepatology

Nom court de la revue :

Clin Gastroenterol Hepatol

Date de publication :

2021-01-28

ISSN :

1542-7714

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

OBJECTIVE: Alcoholic hepatitis (AH) is a severe condition with poor short-term prognosis. Specific treatment with corticosteroids slightly improves short-term survival but is associated with infection and is not used in ...
Lire la suite >OBJECTIVE: Alcoholic hepatitis (AH) is a severe condition with poor short-term prognosis. Specific treatment with corticosteroids slightly improves short-term survival but is associated with infection and is not used in many centers. A reliable method to identify patients who will recover spontaneously will minimise the numbers of patients who experience side effects of available treatments. METHODS: We analysed the trajectory of serum bilirubin concentration over the course of hospital admissions in patients with AH to predict spontaneous survival and the need for treatment. RESULTS: data from 426 patients were analysed. Based on bilirubin trajectory, patients were categorized into three groups: 'fast fallers' (bilirubin <0.8 x admission value at day 7), 'static' (bilirubin of >0.9 - <1.2 x admission value) and 'rapid risers' (bilirubin of ≥1.2 x admission bilirubin). Fast fallers had significantly better 90-day survival compared to other groups (log rank p < .001), and showed no benefit of corticosteroid therapy (OR for survival at 28 days of treatment, 0.94, 95% CI 0.06 - 8.41). These findings remained even amongst patients with severe disease based on initial DF, GAHS or MELD scores. CONCLUSIONS: We present an intuitive method of classifying patients with AH based on the trajectory of bilirubin over the first week of admission. It is complimentary to existing scores that identify candidates for corticosteroid treatment or assess response to treatment. This method identifies a group of patients with AH who recover spontaneously and can avoid corticosteroid therapy.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

CHU Lille
Inserm
Université de Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Date de dépôt :

2021-07-06T12:44:47Z
2024-03-05T09:04:15Z