Title :

Genome-wide association study and meta-analysis on alcohol-related liver cirrhosis identifies novel genetic risk factors

Author(s) :

Schwantes-An, Tae-Hwi [Auteur]
Darlay, Rebecca [Auteur]
Mathurin, Philippe [Auteur]
Masson, Steven [Auteur]
Liangpunsakul, Suthat [Auteur]
Mueller, Sebastian [Auteur]
Aithal, Guruprasad P. [Auteur]
Eyer, Florian [Auteur]
Gleeson, Dermot [Auteur]
Thompson, Andrew [Auteur]
Müllhaupt, Beat [Auteur]
Stickel, Felix [Auteur]
Soyka, Michael [Auteur]
Goldman, David [Auteur]
Liang, Tiebing [Auteur]
Lumeng, Lawrence [Auteur]
Pirmohamed, Munir [Auteur]
Nalpas, Bertrand [Auteur]
Jacquet, Jean-Marc [Auteur]
Moirand, Romain [Auteur]
Nahon, Pierre [Auteur]
Naveau, Sylvie [Auteur]
Perney, Pascal [Auteur]
Botwin, Greg [Auteur]
Haber, Paul S. [Auteur]
Seitz, Helmut K. [Auteur]
Day, Christopher P. [Auteur]
Foroud, Tatiana M. [Auteur]
Daly, Ann K. [Auteur]
Cordell, Heather J. [Auteur]
Whitfield, John B. [Auteur]
Morgan, Timothy R. [Auteur]
Seth, Devanshi [Auteur]

Journal title :

Hepatology (Baltimore, Md.)

Abbreviated title :

Hepatology

Publication date :

2020-08-27

ISSN :

1527-3350

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

OBJECTIVE: Only a minority of heavy drinkers progress to alcohol-associated cirrhosis (ALC). The aim of this study was to identify common genetic variants that underlie risk for ALC. We analyzed data from 1,128 subjects ...
Show more >OBJECTIVE: Only a minority of heavy drinkers progress to alcohol-associated cirrhosis (ALC). The aim of this study was to identify common genetic variants that underlie risk for ALC. We analyzed data from 1,128 subjects of European ancestry with ALC and 614 heavy-drinking subjects without known liver disease from Australia, the United States, the United Kingdom, and three countries in Europe. A genome-wide association study (GWAS) was performed, adjusting for principal components and clinical covariates (alcohol use, age, sex, body mass index, and diabetes). We validated our GWAS findings using UK Biobank. We then performed a meta-analysis combining data from our study, the UK Biobank, and a previously published GWAS. Our GWAS found genome-wide significant risk association of rs738409 in patatin-like phospholipase domain containing 3 (PNPLA3) (odds ratio [OR] = 2.19 [G allele], P = 4.93 × 10-17-10-8 CONCLUSIONS: Our genetic findings implicate lipid droplets in the biological pathway(s) underlying ALC.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
Inserm
Université de Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2021-07-06T12:45:04Z