Are pregnancies with lupus but without aps of good prognosis?

Document type :

Article dans une revue scientifique: Lettre à l'éditeur

DOI :

10.1016/j.autrev.2020.102489

PMID :

Permalink :

http://hdl.handle.net/20.500.12210/40584

Title :

Are pregnancies with lupus but without aps of good prognosis?

Author(s) :

Marx-Deseure, Aurore [Auteur]
Labreuche, Julien [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Launay, David [Auteur]

Lille Inflammation Research International Center - U 995 [LIRIC]
Depret, Sandrine [Auteur]
Subtil, Damien [Auteur]

METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Journal title :

Autoimmunity Reviews

Abbreviated title :

Autoimmun Rev

Volume number :

19

Pages :

102489

Publication date :

2020-04

ISSN :

1873-0183

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

BACKGROUND: Pregnancies in women with systemic lupus erythematosus (SLE) are at risk of unfavorable perinatal outcomes, especially when antiphospholipid antibody syndrome (APS) is present. Their prognosis is less clear in ...
Show more >BACKGROUND: Pregnancies in women with systemic lupus erythematosus (SLE) are at risk of unfavorable perinatal outcomes, especially when antiphospholipid antibody syndrome (APS) is present. Their prognosis is less clear in other situations. OBJECTIVE: To assess pregnancy prognosis in women with SLE but not APS compared with a control series and determine the poor prognostic factors, if any, detectable before 15 weeks' gestation. METHODS: This retrospective case-control study included 137 women with SLE, including 114 without APS, and 274 control women. Unfavorable perinatal outcome was defined by perinatal death (≥ 22 weeks of gestation) or preterm delivery ≤35 weeks. RESULTS: Pregnancies of the 114 women with SLE but not APS were at more than twice the risk of unfavorable perinatal outcomes compared with those in the control group (18/114 (15.8%) vs 21/274 (7.7%), OR 2.3, 95% 1.1-4.7). After logistic regression, three factors detectable before 15 weeks were associated with an unfavorable perinatal outcome: i. proteinuria and/or hypertension (in 19.3% of the pregnancies) ii. lack of cutaneous lupus (26.3%), and iii. a history of thrombocytopenia-leukopenia-anemia (19.3%). When these factors were absent, the risk of a poor perinatal outcome was very low (3.3%) but increased strongly for pregnancies with one (22.2%) or at least two (44.4%) of these factors. CONCLUSIONS: Among women with SLE but not APS in the first trimester, only the presence of risk factors increases the likelihood of an unfavorable perinatal outcome. CONCLUSIONS: Pregnancies with SLE but not APS are at risk of unfavorable perinatal outcomes only if risk factors are present.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
Inserm
Université de Lille

Collections :

Submission date :

2021-07-06T12:45:33Z
2024-01-10T09:27:32Z

Version history