Total polyphenol intake is inversely ...
Type de document :
Article dans une revue scientifique: Article original
DOI :
PMID :
URL permanente :
Titre :
Total polyphenol intake is inversely associated with a pro/anti-inflammatory biomarker ratio in european adolescents of the helena study
Auteur(s) :
Wisnuwardani, Ratih Wirapuspita [Auteur]
Universiteit Gent = Ghent University [UGENT]
De Henauw, Stefaan [Auteur]
Universiteit Gent = Ghent University [UGENT]
Ferrari, Marika [Auteur]
Consiglio per la Ricerca in Agricoltura e l’analisi dell’economia agraria = Council for Agricultural Research and Economics [CREA]
Forsner, Maria [Auteur]
Dalarna University
gottrand, Fréderic [Auteur]
Lille Inflammation Research International Center (LIRIC) - U995
Huybrechts, Inge [Auteur]
Centre International de Recherche contre le Cancer - International Agency for Research on Cancer [CIRC - IARC]
Universiteit Gent = Ghent University [UGENT]
Kafatos, Antonios G. [Auteur]
University of Crete [Heraklion] [UOC]
Kersting, Mathilde [Auteur]
Knaze, Viktoria [Auteur]
Centre International de Recherche contre le Cancer - International Agency for Research on Cancer [CIRC - IARC]
Manios, Yannis [Auteur]
Harokopio University of Athens
Marcos, Ascension [Auteur]
Consejo Superior de Investigaciones Cientificas [España] = Spanish National Research Council [Spain] [CSIC]
Molnar, Denes [Auteur]
University of Pecs
Rothwell, Joseph A. [Auteur]
Centre International de Recherche contre le Cancer - International Agency for Research on Cancer [CIRC - IARC]
Ruperez, Azahara Iris [Auteur]
University of Zaragoza - Universidad de Zaragoza [Zaragoza]
Scalbert, Augustin [Auteur]
Centre International de Recherche contre le Cancer - International Agency for Research on Cancer [CIRC - IARC]
Widhalm, Kurt [Auteur]
Medizinische Universität Wien = Medical University of Vienna
Moreno, Luis Aznar [Auteur]
University of Zaragoza - Universidad de Zaragoza [Zaragoza]
Michels, Nathalie [Auteur]
Universiteit Gent = Ghent University [UGENT]
Universiteit Gent = Ghent University [UGENT]
De Henauw, Stefaan [Auteur]
Universiteit Gent = Ghent University [UGENT]
Ferrari, Marika [Auteur]
Consiglio per la Ricerca in Agricoltura e l’analisi dell’economia agraria = Council for Agricultural Research and Economics [CREA]
Forsner, Maria [Auteur]
Dalarna University
gottrand, Fréderic [Auteur]
Lille Inflammation Research International Center (LIRIC) - U995
Huybrechts, Inge [Auteur]
Centre International de Recherche contre le Cancer - International Agency for Research on Cancer [CIRC - IARC]
Universiteit Gent = Ghent University [UGENT]
Kafatos, Antonios G. [Auteur]
University of Crete [Heraklion] [UOC]
Kersting, Mathilde [Auteur]
Knaze, Viktoria [Auteur]
Centre International de Recherche contre le Cancer - International Agency for Research on Cancer [CIRC - IARC]
Manios, Yannis [Auteur]
Harokopio University of Athens
Marcos, Ascension [Auteur]
Consejo Superior de Investigaciones Cientificas [España] = Spanish National Research Council [Spain] [CSIC]
Molnar, Denes [Auteur]
University of Pecs
Rothwell, Joseph A. [Auteur]
Centre International de Recherche contre le Cancer - International Agency for Research on Cancer [CIRC - IARC]
Ruperez, Azahara Iris [Auteur]
University of Zaragoza - Universidad de Zaragoza [Zaragoza]
Scalbert, Augustin [Auteur]
Centre International de Recherche contre le Cancer - International Agency for Research on Cancer [CIRC - IARC]
Widhalm, Kurt [Auteur]
Medizinische Universität Wien = Medical University of Vienna
Moreno, Luis Aznar [Auteur]
University of Zaragoza - Universidad de Zaragoza [Zaragoza]
Michels, Nathalie [Auteur]
Universiteit Gent = Ghent University [UGENT]
Titre de la revue :
The Journal of Nutrition
Nom court de la revue :
J. Nutr.
Numéro :
150
Pagination :
1610–1618
Éditeur :
Oxford Academic
Date de publication :
2020-03-28
ISSN :
1541-6100
Mot(s)-clé(s) :
polyphenol
adolescent
youth
flavonoid
proanthocyanidin
inflammation
cytokines
adolescent
youth
flavonoid
proanthocyanidin
inflammation
cytokines
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
Although high dietary polyphenol intake is negatively associated with risk of certain inflammation-associated chronic diseases, the underlying mechanisms are not fully understood and few studies have explored this in ...
Lire la suite >Although high dietary polyphenol intake is negatively associated with risk of certain inflammation-associated chronic diseases, the underlying mechanisms are not fully understood and few studies have explored this in adolescents. This study aimed to evaluate the association between intakes of total polyphenols, polyphenol classes, and the 10 most commonly consumed individual polyphenols with inflammatory biomarkers in the blood of European adolescents. In the Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) Study, 526 adolescents (54% girls; 12.5-17.5 y) had data on inflammatory biomarkers and polyphenol intake from 2 nonconsecutive 24-h recalls via matching with the Phenol-Explorer database. Inflammatory biomarkers in serum were IL-1, IL-2, IL-4, IL-5, IL-6, IL-10, transforming growth factor β1 (TGF-β1), TNF-α, IFN-γ, soluble vascular adhesion molecule 1 (sVCAM-1), soluble intercellular adhesion molecule 1 (sICAM-1), soluble E-selectin (sE-selectin), white blood cells, lymphocytes, T cells, and C-reactive protein. Multilevel linear models were used to test associations of polyphenol intake with a pro/anti-inflammatory biomarker ratio [(zTNF-α + zIL-6 + zIL-1)/3/zIL-10] as well as with separate inflammatory biomarkers, adjusted for sociodemographic variables, diet inflammation index, BMI z score, and serum triglycerides. The pro/anti-inflammatory biomarker ratio was linearly inversely associated with the intake of total polyphenols (β = -0.11, P = 0.040). When other inflammation biomarkers were considered, the serum IL-10 concentration was inversely associated with total polyphenol (β = -0.12, P = 0.017) and flavonoid (β = -0.12, P = 0.013) intakes, findings that were inconsistent with the biomarker ratio results. However, the anti-inflammatory capacity of polyphenols was confirmed by positive associations of IL-4 with phenolic acid (β = 0.09 P = 0.049) and stilbene (β = 0.13, P = 0.019) intakes and the negative association of IL-1, IL-2, and IFN-γ with lignan intake (β = -0.10, P = 0.034; β = -0.09, P = 0.049; β = -0.11, P = 0.023). The negative relation with the overall pro/anti-inflammatory biomarker ratio suggests a potential anti-inflammatory role of high polyphenol intakes among European adolescents. Nevertheless, associations are dependent on polyphenol type and the inflammatory biomarker measured.Lire moins >
Lire la suite >Although high dietary polyphenol intake is negatively associated with risk of certain inflammation-associated chronic diseases, the underlying mechanisms are not fully understood and few studies have explored this in adolescents. This study aimed to evaluate the association between intakes of total polyphenols, polyphenol classes, and the 10 most commonly consumed individual polyphenols with inflammatory biomarkers in the blood of European adolescents. In the Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) Study, 526 adolescents (54% girls; 12.5-17.5 y) had data on inflammatory biomarkers and polyphenol intake from 2 nonconsecutive 24-h recalls via matching with the Phenol-Explorer database. Inflammatory biomarkers in serum were IL-1, IL-2, IL-4, IL-5, IL-6, IL-10, transforming growth factor β1 (TGF-β1), TNF-α, IFN-γ, soluble vascular adhesion molecule 1 (sVCAM-1), soluble intercellular adhesion molecule 1 (sICAM-1), soluble E-selectin (sE-selectin), white blood cells, lymphocytes, T cells, and C-reactive protein. Multilevel linear models were used to test associations of polyphenol intake with a pro/anti-inflammatory biomarker ratio [(zTNF-α + zIL-6 + zIL-1)/3/zIL-10] as well as with separate inflammatory biomarkers, adjusted for sociodemographic variables, diet inflammation index, BMI z score, and serum triglycerides. The pro/anti-inflammatory biomarker ratio was linearly inversely associated with the intake of total polyphenols (β = -0.11, P = 0.040). When other inflammation biomarkers were considered, the serum IL-10 concentration was inversely associated with total polyphenol (β = -0.12, P = 0.017) and flavonoid (β = -0.12, P = 0.013) intakes, findings that were inconsistent with the biomarker ratio results. However, the anti-inflammatory capacity of polyphenols was confirmed by positive associations of IL-4 with phenolic acid (β = 0.09 P = 0.049) and stilbene (β = 0.13, P = 0.019) intakes and the negative association of IL-1, IL-2, and IFN-γ with lignan intake (β = -0.10, P = 0.034; β = -0.09, P = 0.049; β = -0.11, P = 0.023). The negative relation with the overall pro/anti-inflammatory biomarker ratio suggests a potential anti-inflammatory role of high polyphenol intakes among European adolescents. Nevertheless, associations are dependent on polyphenol type and the inflammatory biomarker measured.Lire moins >
Langue :
Anglais
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
CHU Lille
Inserm
Université de Lille
Inserm
Université de Lille
Date de dépôt :
2021-07-06T12:47:21Z
2023-03-22T08:36:21Z
2023-04-28T11:09:19Z
2023-03-22T08:36:21Z
2023-04-28T11:09:19Z
Fichiers
- 1-s2.0-S0022316622021988-main.pdf
- Version éditeur
- Accès restreint
- Accéder au document