Title :

Outcomes of pregnancy and associated factors in sub-saharan african women with systemic lupus erythematosus: a scoping review

Author(s) :

Essouma, Mickael [Auteur]
Nkeck, Jan Rene [Auteur]
Motolouze, Kodoume [Auteur]
Bigna, Jean Joel [Auteur]
Tchaptchet, Paul [Auteur]
Nkoro, Grace Anita [Auteur]
Ralandison, Stephane [Auteur]
Hachulla, Eric [Auteur]

Journal title :

Lupus science & medicine

Abbreviated title :

Lupus Sci Med

Volume number :

7

Publication date :

2020-06-01

ISSN :

2053-8790

Keyword(s) :

health care
systemic and outcome assessment
lupus erythematosus
qualitative research

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

To scope and summarise available literature on the outcomes of pregnancy and associated factors in sub-Saharan African women with SLE. Electronic databases and reference lists of retrieved articles were searched to identify ...
Show more >To scope and summarise available literature on the outcomes of pregnancy and associated factors in sub-Saharan African women with SLE. Electronic databases and reference lists of retrieved articles were searched to identify relevant studies published from 1 January 2000 to 28 October 2019. Data were combined through narrative synthesis. We included four studies retrospectively reporting a total of 137 pregnancies in 102 women over a 26-year period. Mean age at conception ranged from 27.2 to 39.9 years. Kidney damage, the predominant organ manifestation before conception, was reported in 43 (42.2%) patients. Ninety-seven (70.8%) pregnancies resulted in 98 live births. SLE flares occurred in 44 (32.2%) pregnancies, mainly skin (20.4%) and renal (18.2%) flares. Major adverse pregnancy outcomes (APOs) were preterm birth 38.8%, low birth weight 29.8%, pregnancy loss 29.2% and pre-eclampsia 24.8%. The main factors associated with APOs were nephritis and SLE flares. Over two-thirds of pregnancies resulted in live birth in this cohort of sub-Saharan African women with SLE. The main APOs and associated factors described in other parts of the world are also seen in this region, but with high rates of APOs. A large prospective multinational study is warranted for more compelling evidence.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
Inserm
Université de Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2021-07-06T12:47:23Z