Title :

Impact of the covid-19 epidemic on the mortality of kidney transplant recipients and candidates in a french nationwide registry study (important)

Author(s) :

Thaunat, Olivier [Auteur]
Centre International de Recherche en Infectiologie [CIRI]
Hôpital Edouard Herriot [CHU - HCL]
Université Claude Bernard Lyon 1 [UCBL]
Legeai, Camille [Auteur]
Agence de la biomédecine [Saint-Denis la Plaine]
Anglicheau, Dany [Auteur]
Service Néphrologie et transplantation rénale Adultes [CHU Necker]
Couzi, Lionel [Auteur]
Service de Néphrologie-transplantation-dialyse [Bordeaux]
Blancho, Gilles [Auteur]
Institut de transplantation urologie-néphrologie [ITUN]
Centre de Recherche en Transplantation et Immunologie - Center for Research in Transplantation and Translational Immunology [U1064 Inserm - CR2TI]
Nantes Université [Nantes Univ]
Hazzan, Marc [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Pastural, Myriam [Auteur]
Agence de la biomédecine [Saint-Denis la Plaine]
Savoye, Emilie [Auteur]
Agence de la biomédecine [Saint-Denis la Plaine]
Bayer, Florian [Auteur]
Agence de la biomédecine [Saint-Denis la Plaine]
Morelon, Emmanuel [Auteur]
Hôpital Edouard Herriot [CHU - HCL]
Université Claude Bernard Lyon 1 [UCBL]
Le Meur, Yann [Auteur]
CHRU Brest - Service de Nephrologie [CHU - BREST - Nephrologie]
Bastien, Olivier [Auteur]
Agence de la biomédecine [Saint-Denis la Plaine]
Caillard, Sophie [Auteur]
Centre Hospitalier Universitaire [Strasbourg] [CHU Strasbourg]

Journal title :

Kidney International

Abbreviated title :

Kidney Int

Publication date :

2020-10-30

ISSN :

1523-1755

Keyword(s) :

mortality
SARS-CoV-2
renal transplantation
ESRD
COVID-19

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

End stage kidney disease increase the risk of COVID-19 related death but how the kidney replacement strategy should be adapted during the pandemic is unknown. Chronic hemodialysis makes social distancing difficult to ...
Show more >End stage kidney disease increase the risk of COVID-19 related death but how the kidney replacement strategy should be adapted during the pandemic is unknown. Chronic hemodialysis makes social distancing difficult to achieve. Alternatively, kidney transplantation could increase the severity of COVID-19 due to therapeutic immunosuppression and contribute to saturation of intensive care units. For these reasons, kidney transplantation was suspended in France during the first epidemic wave. Here, we retrospectively evaluated this strategy by comparing the overall and COVID-19 related mortality in kidney transplant recipients and candidates over the last three years. Cross-interrogation of two national registries for the period 1 March and 1 June 2020, identified 275 deaths among the 42812 kidney transplant recipients and 144 deaths among the 16210 candidates. This represents an excess of deaths for both populations, as compared with the same period the two previous years (mean of two previous years: 253 in recipients and 112 in candidates). This difference was integrally explained by COVID-19, which accounted for 44% (122) and 42% (60) of the deaths in recipients and candidates, respectively. Taking into account the size of the two populations and the geographical heterogeneity of virus circulation, we found that the excess of risk of death due to COVID-19 was similar for recipients and candidates in high viral risk area but four-fold higher for candidates in the low viral risk area. Thus, in case of a second epidemic wave, kidney transplantation should be suspended in high viral risk areas but maintained outside those areas, both to reduce the excess of deaths of candidates and avoid wasting precious resources.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
Inserm
Université de Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2021-07-06T12:48:42Z
2024-03-29T16:36:48Z