Titre :

Cd34+ cell selection methods, quality controls and expected results: guidelines from the francophone society of bone marrow transplantation and cellular therapy (sfgm-tc)

Auteur(s) :

Calmels, Boris [Auteur]
Gautier, Eric [Auteur]
Magnani, Alessandra [Auteur]
Magrin, Elisa [Auteur]
Mamez, Anne-Claire [Auteur]
Vaissié, Alix [Auteur]
Yakoub-Agha, Ibrahim [Auteur]
Baudoux, Etienne [Auteur]

Titre de la revue :

Bulletin du cancer

Nom court de la revue :

Bull Cancer

Date de publication :

2020-10-07

ISSN :

1769-6917

Mot(s)-clé(s) :

CD34 selection
Boost
Allogeneic transplantation

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

CD34+ immunomagnetic positive selection allows for CD34+ hematopoietic progenitors separation from CD3+ lymphocytes subsets, usually from an apheresis product collected from a previously mobilized donor. This T-cell depleted ...
Lire la suite >CD34+ immunomagnetic positive selection allows for CD34+ hematopoietic progenitors separation from CD3+ lymphocytes subsets, usually from an apheresis product collected from a previously mobilized donor. This T-cell depleted stem cell graft is primarily intended for rare cases (around 2% of allotransplanted patients in France) of severe, persistent, symptomatic bi- or tri-cytopenia post-allotransplantation, in order to allow for hematologic reconstitution without increasing the risk of GvHD occurrence. Although semi-manual and complex, the process is of sufficient robustness to consistently generate a cellular product with distinctive features and specifications, based on iterative in-process quality controls, that are discussed within these guidelines.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

CHU Lille
Inserm
Université de Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Date de dépôt :

2021-07-06T12:48:45Z