Obstetrical outcome and treatments in ...
Type de document :
Article dans une revue scientifique: Article original
PMID :
URL permanente :
Titre :
Obstetrical outcome and treatments in seronegative primary aps: data from european retrospective study
Auteur(s) :
Abisror, Noemie [Auteur]
CHU Saint-Antoine [AP-HP]
Nguyen, Yann [Auteur]
Hôpital Beaujon [AP-HP]
Marozio, Luca [Auteur]
Università degli studi di Torino = University of Turin [UNITO]
Esteve Valverde, Enrique [Auteur]
Udry, Sebastian [Auteur]
Pleguezuelo, Daniel Enrique [Auteur]
Hospital Universitario 12 de Octubre [Madrid]
Billoir, Paul [Auteur]
Service de Médecine Interne [CHU Rouen]
Mayer-Pickel, Karoline [Auteur]
Urbanski, Geoffrey [Auteur]
Service de médecine interne et gérontologie clinique [Angers]
Zigon, Polona [Auteur]
University Medical Centre Ljubljana [Ljubljana, Slovenia] [UMCL]
De Moreuil, Claire [Auteur]
Département de Médecine Interne et Pneumologie [Brest] [DMIP - Brest]
Groupe d'Etude de la Thrombose de Bretagne Occidentale [GETBO]
Hoxha, Ariela [Auteur]
Azienda Ospedale Università di Padova = Hospital-University of Padua [AOUP]
Bezanahary, Holy [Auteur]
Service de Médecine interne A et polyclinique médicale [CHU Limoges]
Carbillon, Lionel [Auteur]
Assistance publique - Hôpitaux de Paris (AP-HP) [AP-HP]
Kayem, Gilles [Auteur]
CHU Trousseau [APHP]
Sorbonne Université [SU]
Bornes, Marie [Auteur]
CHU Tenon [AP-HP]
Le Carpentier, Cécile [Auteur]
Centre National de Référence des Maladies Auto-Immunes Systémiques Rares du Nord et Nord-Ouest de France [CeRAINO]
Johanet, Cathererine [Auteur]
CHU Saint-Antoine [AP-HP]
Nicaise-Roland, Pascale [Auteur]
AP-HP - Hôpital Bichat - Claude Bernard [Paris]
Lambert, Marc [Auteur]
Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement (RID-AGE) - U1167
Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement (RID-AGE) - U1167
Centre National de Référence des Maladies Auto-Immunes Systémiques Rares du Nord et Nord-Ouest de France [CeRAINO]
Salle, Valery [Auteur]
CHU Amiens-Picardie
Latino, Omar Jose [Auteur]
Hachulla, Eric [Auteur]
Centre National de Référence des Maladies Auto-Immunes Systémiques Rares du Nord et Nord-Ouest de France [CeRAINO]
Benedetto, Chiara [Auteur]
Università degli studi di Torino = University of Turin [UNITO]
Bourrienne, Marie Charlotte [Auteur]
CIC - CHU Bichat
Laboratoire de Recherche Vasculaire Translationnelle [LVTS (UMR_S_1148 / U1148)]
Benhamou, Ygal [Auteur]
Service de Médecine Interne [CHU Rouen]
Alijotas-Reig, Jaume [Auteur]
Vall d'Hebron University Hospital [Barcelona]
Fain, Olivier [Auteur]
CHU Saint-Antoine [AP-HP]
Mekinian, Arsene [Auteur]
CHU Saint-Antoine [AP-HP]
CHU Saint-Antoine [AP-HP]
Nguyen, Yann [Auteur]
Hôpital Beaujon [AP-HP]
Marozio, Luca [Auteur]
Università degli studi di Torino = University of Turin [UNITO]
Esteve Valverde, Enrique [Auteur]
Udry, Sebastian [Auteur]
Pleguezuelo, Daniel Enrique [Auteur]
Hospital Universitario 12 de Octubre [Madrid]
Billoir, Paul [Auteur]
Service de Médecine Interne [CHU Rouen]
Mayer-Pickel, Karoline [Auteur]
Urbanski, Geoffrey [Auteur]
Service de médecine interne et gérontologie clinique [Angers]
Zigon, Polona [Auteur]
University Medical Centre Ljubljana [Ljubljana, Slovenia] [UMCL]
De Moreuil, Claire [Auteur]
Département de Médecine Interne et Pneumologie [Brest] [DMIP - Brest]
Groupe d'Etude de la Thrombose de Bretagne Occidentale [GETBO]
Hoxha, Ariela [Auteur]
Azienda Ospedale Università di Padova = Hospital-University of Padua [AOUP]
Bezanahary, Holy [Auteur]
Service de Médecine interne A et polyclinique médicale [CHU Limoges]
Carbillon, Lionel [Auteur]
Assistance publique - Hôpitaux de Paris (AP-HP) [AP-HP]
Kayem, Gilles [Auteur]
CHU Trousseau [APHP]
Sorbonne Université [SU]
Bornes, Marie [Auteur]
CHU Tenon [AP-HP]
Le Carpentier, Cécile [Auteur]
Centre National de Référence des Maladies Auto-Immunes Systémiques Rares du Nord et Nord-Ouest de France [CeRAINO]
Johanet, Cathererine [Auteur]
CHU Saint-Antoine [AP-HP]
Nicaise-Roland, Pascale [Auteur]
AP-HP - Hôpital Bichat - Claude Bernard [Paris]
Lambert, Marc [Auteur]
Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement (RID-AGE) - U1167
Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement (RID-AGE) - U1167
Centre National de Référence des Maladies Auto-Immunes Systémiques Rares du Nord et Nord-Ouest de France [CeRAINO]
Salle, Valery [Auteur]
CHU Amiens-Picardie
Latino, Omar Jose [Auteur]
Hachulla, Eric [Auteur]
Centre National de Référence des Maladies Auto-Immunes Systémiques Rares du Nord et Nord-Ouest de France [CeRAINO]
Benedetto, Chiara [Auteur]
Università degli studi di Torino = University of Turin [UNITO]
Bourrienne, Marie Charlotte [Auteur]
CIC - CHU Bichat
Laboratoire de Recherche Vasculaire Translationnelle [LVTS (UMR_S_1148 / U1148)]
Benhamou, Ygal [Auteur]
Service de Médecine Interne [CHU Rouen]
Alijotas-Reig, Jaume [Auteur]
Vall d'Hebron University Hospital [Barcelona]
Fain, Olivier [Auteur]
CHU Saint-Antoine [AP-HP]
Mekinian, Arsene [Auteur]
CHU Saint-Antoine [AP-HP]
Titre de la revue :
RMD open
Nom court de la revue :
RMD Open
Numéro :
6
Pagination :
0
Date de publication :
2020-08-01
ISSN :
2056-5933
Mot(s)-clé(s) :
Antiphospholipid
Antibodies
Health Care
Outcome and Process Assessment
Antiphospholipid Syndrome
Antibodies
Health Care
Outcome and Process Assessment
Antiphospholipid Syndrome
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
To compare characteristics, pregnancies and treatments during pregnancies of seronegative and seropositive antiphospholipid syndrome (APS), to analyse factors associated with obstetrical outcome.
Inclusion criteria were: ...
Lire la suite >To compare characteristics, pregnancies and treatments during pregnancies of seronegative and seropositive antiphospholipid syndrome (APS), to analyse factors associated with obstetrical outcome. Inclusion criteria were: (1) thrombotic and/or obstetrical APS (Sydney criteria); (2) absence of conventional antiphospholipid antibodies (APL); (3) at least one persistent non-conventional APL among IgA anticardiolipin antibodies, IgA anti-B2GPI, anti-vimentin G/M, anti-annexin V G/M, anti-phosphatidylethanolamine G/M and anti-phosphatidylserine/prothrombin G/M antibodies. The exclusion criteria were: (1) systemic lupus erythematosus ( SLE) or SLE-like disease; and (2) other connective tissue disease. A total of 187 women (mean 33±5 years) with seronegative APS were included from 14 centres in Austria, Spain, Italy, Slovenia and France and compared with 285 patients with seropositive APS. Seronegative APS has more obstetrical rather than thrombotic phenotypes, with only 6% of venous thrombosis in comparison to seropositive APS. Cumulative incidence of adverse obstetrical events was similar in seronegative and seropositive APS patients, although higher rates of intrauterine deaths (15% vs 5%; p=0.03), of preeclampsia (7% vs 16%, p=0.048) and lower live birth term (36±3 vs 38±3 weeks of gestation; p=0.04) were noted in seropositive APS. The cumulative incidence of adverse obstetrical events was significantly improved in treated versus untreated seronegative APS (log rank<0.05), whereas there was no difference between patients who received aspirin or aspirin-low-molecular weighted heparin combination. Several non-criteria APL can be detected in patients with clinical APS features without any conventional APL, with various rates. The detection of non-criteria APL and thus the diagnosis of seronegative APS could discuss the therapeutic management similar to seropositive APS, but well-designed controlled studies are necessary.Lire moins >
Lire la suite >To compare characteristics, pregnancies and treatments during pregnancies of seronegative and seropositive antiphospholipid syndrome (APS), to analyse factors associated with obstetrical outcome. Inclusion criteria were: (1) thrombotic and/or obstetrical APS (Sydney criteria); (2) absence of conventional antiphospholipid antibodies (APL); (3) at least one persistent non-conventional APL among IgA anticardiolipin antibodies, IgA anti-B2GPI, anti-vimentin G/M, anti-annexin V G/M, anti-phosphatidylethanolamine G/M and anti-phosphatidylserine/prothrombin G/M antibodies. The exclusion criteria were: (1) systemic lupus erythematosus ( SLE) or SLE-like disease; and (2) other connective tissue disease. A total of 187 women (mean 33±5 years) with seronegative APS were included from 14 centres in Austria, Spain, Italy, Slovenia and France and compared with 285 patients with seropositive APS. Seronegative APS has more obstetrical rather than thrombotic phenotypes, with only 6% of venous thrombosis in comparison to seropositive APS. Cumulative incidence of adverse obstetrical events was similar in seronegative and seropositive APS patients, although higher rates of intrauterine deaths (15% vs 5%; p=0.03), of preeclampsia (7% vs 16%, p=0.048) and lower live birth term (36±3 vs 38±3 weeks of gestation; p=0.04) were noted in seropositive APS. The cumulative incidence of adverse obstetrical events was significantly improved in treated versus untreated seronegative APS (log rank<0.05), whereas there was no difference between patients who received aspirin or aspirin-low-molecular weighted heparin combination. Several non-criteria APL can be detected in patients with clinical APS features without any conventional APL, with various rates. The detection of non-criteria APL and thus the diagnosis of seronegative APS could discuss the therapeutic management similar to seropositive APS, but well-designed controlled studies are necessary.Lire moins >
Langue :
Anglais
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
CHU Lille
Inserm
Institut Pasteur de Lille
Université de Lille
Inserm
Institut Pasteur de Lille
Université de Lille
Collections :
Date de dépôt :
2021-07-06T12:49:21Z
2024-02-05T10:58:03Z
2024-02-05T10:58:03Z
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