Titre :

Mortality in systemic necrotizing vasculitides: A retrospective analysis of the French Vasculitis Study Group registry.

Auteur(s) :

Jardel, Sabine [Auteur]
Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 [LBBE]
Puechal, Xavier [Auteur]
Université Paris Descartes - Paris 5 [UPD5]
Le Quellec, Alain [Auteur]
Université de Montpellier [UM]
Pagnoux, Christian [Auteur]
Université Paris Descartes - Paris 5 [UPD5]
Hamidou, Mohamed [Auteur]
Maurier, Francois [Auteur]
Aumaitre, Olivier [Auteur]
Aouba, Achille [Auteur]
Université de Caen Normandie [UNICAEN]
Quemeneur, Thomas [Auteur]
Subra, Jean-Francois [Auteur]
Cottin, Vincent [Auteur]
Université Claude Bernard Lyon 1 [UCBL]
Sibilia, Jean [Auteur]
Godmer, Pascal [Auteur]
Cacoub, Patrice [Auteur]
Université Pierre et Marie Curie - Paris 6 [UPMC]
Fauchais, Anne-Laure [Auteur]
Hachulla, Eric [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Guillevin, Loic [Auteur]
Université Paris Cité [UPCité]
Lega, Jean-Christophe [Auteur]
Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 [LBBE]

Titre de la revue :

Autoimmunity Reviews

Nom court de la revue :

Autoimmun. Rev.

Numéro :

17

Pagination :

653-659

Date de publication :

2018-07

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Objective: The aim of the study was to describe the evolution of mortality and cause-specific mortality over time in patients with systemic necrotizing vasculitides (SNV), including polyarteritis nodosa (PAN), granulomatosis ...
Lire la suite >Objective: The aim of the study was to describe the evolution of mortality and cause-specific mortality over time in patients with systemic necrotizing vasculitides (SNV), including polyarteritis nodosa (PAN), granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), and eosinophilic granulomatosis with polyangiitis (EGPA). Methods: Patients with SNV from the French Vasculitis Study Group registry were divided into 5 groups according to the date of diagnosis: <1980, 1980–1989, 1990–1999, 2000–2010, and ≥ 2010. The causes of death were classified as vasculitis, infection, cardiovascular, malignancy, miscellaneous, or unknown. Results: Among the 2217 patients included (PAN 16.1%, GPA 41.7%, EGPA 22.6%, MPA 19.6%), overall incidence of death was 2.26 per 100 person-years. The overall survival improved during each period considered. The 5-year survival rate increased from 72.2% (95% confidence interval [CI] 59.7–87.2) for patients diagnosed before 1980 to 94.5% (95% CI 90.4–98.8) after 2010 (p < 0.001). Periods of diagnosis, age, and male gender were independently associated with a poor survival with a non-significant difference between vasculitis. The incidence of mortality between the 1980s and after 2010 significantly decreased for vasculitis-related (p = 0.03) and cardiovascular-related deaths (p = 0.04). Incidence of death by infection remained stable between the 1980s and the 2000s but no death by infection occurred after 2010. The incidence of death by malignancy remained stable over time.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Inserm
Université de Lille
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Équipe(s) de recherche :

Immunity, inflammation and fibrsis in auto and allo-reactivity

Date de dépôt :

2019-03-01T14:26:52Z
2024-01-25T12:22:44Z