Title :

Differential Determinants of Tubular Phosphate Reabsorption: Insights on Renal Excretion of Phosphates in Kidney Disease.

Author(s) :

Tabibzadeh, Nahid [Auteur]
Centre Hospitalier Boulogne-sur-mer
Mentaverri, Romuald [Auteur]
Université de Picardie Jules Verne [UPJV]
Daroux, Maite [Auteur]
Lille Inflammation Research International Center (LIRIC) - U995
Lille Inflammation Research International Center - U 995 [LIRIC]
Mesbah, Rafik [Auteur]
Centre Hospitalier Boulogne-sur-mer
Delpierre, Alexia [Auteur]
Paul, Jean-Gabriel [Auteur]
Centre Hospitalier Boulogne-sur-mer
Deken, Valerie [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Massy Ziad, A [Auteur]
Centre de recherche en épidémiologie et santé des populations [CESP]
Hôpital Ambroise Paré [AP-HP]
Université de Versailles Saint-Quentin-en-Yvelines [UVSQ]
Bataille, Pierre [Auteur]
Centre Hospitalier Boulogne-sur-mer

Journal title :

American journal of nephrology

Abbreviated title :

Am. J. Nephrol.

Volume number :

47

Pages :

300-303

Publisher :

Karger

Publication date :

2018-05-18

ISSN :

1421-9670

Keyword(s) :

Fibroblast growth factor 23
Mineral and bone disorders
Tubular phosphate reabsorption
Chronic kidney disease

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

We assessed the tubular reabsorption of phosphate (TRP) and maximal renal threshold for phosphate reabsorption to glomerular filtration rate (TmPi/GFR) and their determinants in 64 stages 2–4 chronic kidney disease (CKD) ...
Show more >We assessed the tubular reabsorption of phosphate (TRP) and maximal renal threshold for phosphate reabsorption to glomerular filtration rate (TmPi/GFR) and their determinants in 64 stages 2–4 chronic kidney disease (CKD) patients in order to define the early changes in phosphate metabolism in CKD. In multivariable analysis, TmPi/GFR correlates were estimated GFR (eGFR), intact parathyroid hormone (iPTH), and hemoglobin (R2 = 0.417), while TRP correlates were eGFR, iPTH, 24-h phosphaturia, and calcitriol (R2 = 0.72). This suggests that TmPi/GFR and TRP, respectively, assess hemoglobin-phosphate and bowel-kidney phosphate regulation axis. Iron supplementation based on TmPi/GFR or earlier phosphate restriction based on TRP should be investigated in view of modifying clinical outcomes in CKD.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Inserm
Université de Lille
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Research team(s) :

Glycation from inflammation to aging

Submission date :

2019-03-01T14:35:30Z
2022-09-21T08:53:19Z