Comparative assessment of local tolerance ...
Type de document :
Article dans une revue scientifique
PMID :
URL permanente :
Titre :
Comparative assessment of local tolerance of alcohols commonly used in alcohol-based hand rubs for hand hygiene
Auteur(s) :
Manche, Monique [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Foligne, Benoit [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE (Ex-Liric)]
Sauty, Mathieu [Auteur]
Institut Pasteur de Lille
Platel, Anne [Auteur]
Impact de l'environnement chimique sur la santé humaine - ULR 4483 [IMPECS]
Vercauteren, Eric [Auteur]
Laboratoire de toxicologie génétique [Lille]
Rauwel, Gaetan [Auteur]
Catoire, Sophie [Auteur]
Ficheux, Herve [Auteur]
Criquelion, Jacques [Auteur]
Nesslany, Fabrice [Auteur]
Impact de l'environnement chimique sur la santé humaine - ULR 4483 [IMPECS]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Foligne, Benoit [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE (Ex-Liric)]
Sauty, Mathieu [Auteur]
Institut Pasteur de Lille
Platel, Anne [Auteur]
Impact de l'environnement chimique sur la santé humaine - ULR 4483 [IMPECS]
Vercauteren, Eric [Auteur]
Laboratoire de toxicologie génétique [Lille]
Rauwel, Gaetan [Auteur]
Catoire, Sophie [Auteur]
Ficheux, Herve [Auteur]
Criquelion, Jacques [Auteur]
Nesslany, Fabrice [Auteur]
Impact de l'environnement chimique sur la santé humaine - ULR 4483 [IMPECS]
Titre de la revue :
Toxicology in Vitro
Nom court de la revue :
Toxicol. Vitro
Numéro :
44
Pagination :
142-153
Éditeur :
Elsevier
Date de publication :
2017-10-01
ISSN :
0887-2333
Mot(s)-clé(s) :
Skin irritation
Hand hygiene
In vitro
Alcohol-based hand rubs
Phototoxicity
Reconstructed human epidermis
Hand hygiene
In vitro
Alcohol-based hand rubs
Phototoxicity
Reconstructed human epidermis
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
Hand hygiene plays a key role in nosocomial infection prevention. To achieve users' adherence, products' dermal tolerance is essential. We aimed at making a comparative assessment of skin irritation and phototoxicity of ...
Lire la suite >Hand hygiene plays a key role in nosocomial infection prevention. To achieve users' adherence, products' dermal tolerance is essential. We aimed at making a comparative assessment of skin irritation and phototoxicity of the 3 alcohols commonly used in alcohol-based hand rubs (Ethanol, Propan-2-ol, Propan-1-ol) at 60, 70, 80 or 85% w/w in water or with co-formulates (hydrating, emollient and skin protective agents). In vitro validated OECD methods 439 and 432 were used. For irritation, EpiSkin™ Small Model was the chosen Reconstructed Human Epidermis (RhE). For phototoxicity, co-formulates alone or in mixture with and without alcohol were tested using BALB/c 3T3 cell cultures. Whilst Ethanol and Propan-2-ol could not be differentiated and displayed good skin tolerance profiles, Propan-1-ol based products lead to significant viability impairments of RhE at 60, 70 or 80% and at 60% in the presence of co-formulates. However, these results could not be reproduced in another RhE model. Taking also into account bibliographic data on Propan-1-ol, this suggests that our results are probably related to a lack of specificity of the used RhE. Therefore, it can be relevant in case of significant results to use two different RhE models before performing any classification and/or performing any complementary tests.Lire moins >
Lire la suite >Hand hygiene plays a key role in nosocomial infection prevention. To achieve users' adherence, products' dermal tolerance is essential. We aimed at making a comparative assessment of skin irritation and phototoxicity of the 3 alcohols commonly used in alcohol-based hand rubs (Ethanol, Propan-2-ol, Propan-1-ol) at 60, 70, 80 or 85% w/w in water or with co-formulates (hydrating, emollient and skin protective agents). In vitro validated OECD methods 439 and 432 were used. For irritation, EpiSkin™ Small Model was the chosen Reconstructed Human Epidermis (RhE). For phototoxicity, co-formulates alone or in mixture with and without alcohol were tested using BALB/c 3T3 cell cultures. Whilst Ethanol and Propan-2-ol could not be differentiated and displayed good skin tolerance profiles, Propan-1-ol based products lead to significant viability impairments of RhE at 60, 70 or 80% and at 60% in the presence of co-formulates. However, these results could not be reproduced in another RhE model. Taking also into account bibliographic data on Propan-1-ol, this suggests that our results are probably related to a lack of specificity of the used RhE. Therefore, it can be relevant in case of significant results to use two different RhE models before performing any classification and/or performing any complementary tests.Lire moins >
Langue :
Anglais
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
Inserm
Université de Lille
CHU Lille
Institut Pasteur de Lille
Université de Lille
CHU Lille
Institut Pasteur de Lille
Collections :
Équipe(s) de recherche :
Inflammatory digestive disease : pathophysiology and therapeutic targets developement
Date de dépôt :
2019-03-01T15:17:11Z
2022-04-27T10:02:04Z
2024-02-15T09:50:47Z
2022-04-27T10:02:04Z
2024-02-15T09:50:47Z
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