Titre :

Activity-dependent changes in the electrophysiological properties of regular spiking neurons in the sensorimotor cortex of the rat in vitro.

Auteur(s) :

Canu, Marie-Hélène [Auteur]
Activité Physique, Muscle, Santé [EA4488]
Picquet, Florence [Auteur]
Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - EA 7369
Bastide, Bruno [Auteur]
Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369
Falempin, Maurice [Auteur]
Activité Physique, Muscle, Santé [EA4488]

Titre de la revue :

Behavioural Brain Research

Nom court de la revue :

Behav Brain Res

Numéro :

209

Pagination :

289-94

Date de publication :

2010-06-19

ISSN :

1872-7549

Mot(s)-clé(s) en anglais :

Action Potentials
Analysis of Variance
Animals
Electrophysiology
Hindlimb
Male
Membrane Potentials
Motor Cortex
Neuronal Plasticity
Neurons
Rats
Rats, Wistar
Sensory Deprivation

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Sensorimotor performance is highly dependent on the level of physical activity. For instance, a period of disuse induces an impairment of motor performance, which is the result of combined muscular, spinal and supraspinal ...
Lire la suite >Sensorimotor performance is highly dependent on the level of physical activity. For instance, a period of disuse induces an impairment of motor performance, which is the result of combined muscular, spinal and supraspinal mechanisms. Concerning this latter origin, our hypothesis was that intrinsic properties and input/output coupling of cells within the sensorimotor cortex might participate to the alteration in cortical motor control. The aim of the present study was thus to examine the basic electrophysiological characteristics of cortical cells in control rats and in animals submitted to 14 days of hindlimb unloading, a model of sensorimotor deprivation. Intracellular recordings were obtained in vitro from coronal slices from cortical hindpaw representation area. We have also made an attempt to determine the morphological characteristics as well as the location of the investigated neurons by biocytin labelling. Passive properties of neurons were affected by hindlimb unloading: input resistance and time constant were decreased (-20%), the rheobase was increased (+34%), whereas the resting potential was unchanged. The frequency-current relationships were also modified, the curve being shifted towards right. The size of body area of recorded neurons was unchanged in unloaded rats. Taken together, these data reflect a decrease in excitability of cortical cells in response to a decreased cortical activation.Lire moins >

Langue :

Anglais

Comité de lecture :

Oui

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
Univ. Artois
Univ. Littoral Côte d’Opale

Collections :

• Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369

Équipe(s) de recherche :

Activité Physique, Muscle, Santé (APMS)

Date de dépôt :

2021-08-10T16:34:32Z
2021-08-23T14:03:13Z