Intercalation of Ciprofloxacin in Naturally ...
Document type :
Article dans une revue scientifique
DOI :
Permalink :
Title :
Intercalation of Ciprofloxacin in Naturally Occurring Smectite from Bana: Potentiality as Drug Delivery System and Antimicrobial Effects on Escherichia coli and Staphylococcus aureus
Author(s) :
Memenfo, Carine Feudjio [Auteur]
Tabary, Nicolas [Auteur]
Unité Matériaux et Transformations (UMET) - UMR 8207
Mbey, Jean Aimé [Auteur]
Degoutin, Stéphanie [Auteur]
Cazaux, Frédéric [Auteur]
Bacquet, maryse [Auteur]
Unité Matériaux et Transformations (UMET) - UMR 8207
Maton, Mickaël [Auteur]
Martel, Bernard [Auteur]
Unité Matériaux et Transformations (UMET) - UMR 8207
Njopwouo, Daniel [Auteur]
Tabary, Nicolas [Auteur]
Unité Matériaux et Transformations (UMET) - UMR 8207
Mbey, Jean Aimé [Auteur]
Degoutin, Stéphanie [Auteur]
Cazaux, Frédéric [Auteur]
Bacquet, maryse [Auteur]
Unité Matériaux et Transformations (UMET) - UMR 8207
Maton, Mickaël [Auteur]
Martel, Bernard [Auteur]
Unité Matériaux et Transformations (UMET) - UMR 8207
Njopwouo, Daniel [Auteur]
Journal title :
Journal of Materials Science and Chemical Engineering
Abbreviated title :
MSCE
Volume number :
09
Pages :
21-40
Publisher :
Scientific Research Publishing, Inc.
Publication date :
2021
English abstract : [en]
Ciprofloxacin (CFX) was loaded on Bana clay (Cameroon) and CFX loadedclays
have been evaluated as drug delivery system. Raw clays and CFX loaded
compounds have been characterized by some physico-chemicals methods. In
vitro ...
Show more >Ciprofloxacin (CFX) was loaded on Bana clay (Cameroon) and CFX loadedclays have been evaluated as drug delivery system. Raw clays and CFX loaded compounds have been characterized by some physico-chemicals methods. In vitro release studies have been done in gastric and phosphate buffer experimental mediums; bacteriological studies have been made up on Escherichia coli and Staphylococcus aureus. X-ray diffractometry patterns of loaded compounds show a basal spacing increasing due to CFX intercalation. On Fourier-Transformed Infrared spectrometry spectra, appearance of CFX characteristic bands and shifting of certain bands already presents on clay confirmed CFX intercalation. After 96 h of CFX released from release mediums, prolonged and continue profiles have been observed. Diffusion tests displayed an inhibition radius of ~2 cm on gelose seeded with Escherichia coli and Staphylococcus aureus due to CFX. The overall results show a modified release of ciprofloxacin with an effective antibacterial activity, giving the way for a new ciprofloxacin drug delivery system using Bana clay as carrier.Show less >
Show more >Ciprofloxacin (CFX) was loaded on Bana clay (Cameroon) and CFX loadedclays have been evaluated as drug delivery system. Raw clays and CFX loaded compounds have been characterized by some physico-chemicals methods. In vitro release studies have been done in gastric and phosphate buffer experimental mediums; bacteriological studies have been made up on Escherichia coli and Staphylococcus aureus. X-ray diffractometry patterns of loaded compounds show a basal spacing increasing due to CFX intercalation. On Fourier-Transformed Infrared spectrometry spectra, appearance of CFX characteristic bands and shifting of certain bands already presents on clay confirmed CFX intercalation. After 96 h of CFX released from release mediums, prolonged and continue profiles have been observed. Diffusion tests displayed an inhibition radius of ~2 cm on gelose seeded with Escherichia coli and Staphylococcus aureus due to CFX. The overall results show a modified release of ciprofloxacin with an effective antibacterial activity, giving the way for a new ciprofloxacin drug delivery system using Bana clay as carrier.Show less >
Language :
Anglais
Peer reviewed article :
Oui
Audience :
Non spécifiée
Administrative institution(s) :
Université de Lille
CNRS
INRA
ENSCL
CNRS
INRA
ENSCL
Collections :
Research team(s) :
Ingénierie des Systèmes Polymères
Submission date :
2021-09-02T13:29:32Z