Titre :

4-Mercaptoimidazoles derived from the naturally occurring antioxidant ovothiols 1. Antioxidant properties

Auteur(s) :

Zoete, Vincent [Auteur]
Ecole Nationale Supérieure de Chimie de Lille [ENSCL]
Bailly, Fabrice [Auteur]
Institut Pasteur de Lille
Vezin, Herve [Auteur]
Ecole Nationale Supérieure de Chimie de Lille [ENSCL]
Teissier, Elisabeth [Auteur]
Institut Pasteur de Lille
Duriez, Patrick [Auteur]
Ecole Nationale Supérieure de Chimie de Lille [ENSCL]
Fruchart, Jean-Charles [Auteur]
Institut Pasteur de Lille
Catteau, Jean-Pierre [Auteur]
Ecole Nationale Supérieure de Chimie de Lille [ENSCL]
Bernier, Jean-Luc [Auteur]
Institut Pasteur de Lille

Titre de la revue :

Free Radical Research

Numéro :

32

Pagination :

515-524

Éditeur :

Informa UK Limited

Date de publication :

2000-01

ISSN :

1029-2470

Mot(s)-clé(s) en anglais :

4-Mercaptoimidazoles
hypochlorous acid
hydrogen peroxide
hydroxyl radical
lipid peroxidation

Discipline(s) HAL :

Chimie/Chimie théorique et/ou physique

Résumé en anglais : [en]

4-Mercaptoimidazoles derived from the naturally occurring family of antioxidants, the ovothiols, were assayed for their antioxidant properties. These compounds are powerful HOCI scavengers, more potent than the aliphatic ...
Lire la suite >4-Mercaptoimidazoles derived from the naturally occurring family of antioxidants, the ovothiols, were assayed for their antioxidant properties. These compounds are powerful HOCI scavengers, more potent than the aliphatic thiol N-acetylcysteine. They react slowly with hydrogen peroxide with second order rate constants of 0.13–0.89 M-1 s-1. Scavenging of hydroxyl radical occurs at a diffusion-controlled rate (k = 2.0–5.0 × 1010 M-1 s-1) for the most active compounds, which are also able to inhibit copper-induced LDL peroxidation. The combination of radical scavenging and copper chelating properties may explain the inhibitory effects on LDL peroxidation. Two molecules of mercaptoimidazole can chelate a copper ion and form a square planar complex detected by EPR. Compounds bearing an electron-withdrawing group on position 2 of the imidazole ring are the most potent antioxidant molecules in this series.Lire moins >

Langue :

Anglais

Comité de lecture :

Oui

Audience :

Internationale

Vulgarisation :

Non

Collections :

• Autres travaux scientifiques

Date de dépôt :

2021-11-03T12:52:35Z
2021-11-09T09:48:55Z
2022-11-08T10:50:17Z