Title :

Water content thresholds in glycerol/water system: Low- and high-wavenumber Raman spectroscopy study

Author(s) :

Starciuc, Tatiana [Auteur]
Unité Matériaux et Transformations (UMET) - UMR 8207
Guinet, Yannick [Auteur]
Unité Matériaux et Transformations (UMET) - UMR 8207
Hedoux, Alain [Auteur]
Unité Matériaux et Transformations (UMET) - UMR 8207
Shalaev, Evgenyi [Auteur]

Journal title :

Journal of Molecular Liquids

Volume number :

321

Pages :

114678

Publisher :

Elsevier

Publication date :

2021-01-01

ISSN :

0167-7322

English keyword(s) :

Water structure
Glycerol
Raman spectroscopy
Hydrogen bonding
Water clusters
Proton transfer

HAL domain(s) :

Chimie
Physique [physics]/Matière Condensée [cond-mat]/Science des matériaux [cond-mat.mtrl-sci]
Physique [physics]/Matière Condensée [cond-mat]/Matière Molle [cond-mat.soft]
Physique [physics]/Matière Condensée [cond-mat]/Systèmes désordonnés et réseaux de neurones [cond-mat.dis-nn]

English abstract : [en]

Water structure is the key in such diverse processes as protein folding, catalysis of chemical reactions, and stability of pharmaceuticals and biopharmaceuticals. In the current investigation, glycerol-water mixtures are ...
Show more >Water structure is the key in such diverse processes as protein folding, catalysis of chemical reactions, and stability of pharmaceuticals and biopharmaceuticals. In the current investigation, glycerol-water mixtures are studied by low- and high-wavenumber Raman spectroscopy. Three water content regions, which are separated by two water content thresholds (WT), WT1 at 6.1 ± 0.7 wt% water and WT2 at 18.6 ± 4.4 wt% water, are identified, based on the trends in the hydrogen bond strength and the cage effect. It is hypothesized that WT1 corresponds to a transition from predominantly unclustered water molecules to small water clusters, and is associated with facilitation of proton transfer as water content exceeds WT1. The WT2 is proposed to mark formation of large (>100 molecules) water clusters, which can form stable nucleus of hexagonal ice at lower temperatures. These findings, if confirmed for other polyhydroxycompounds, could facilitate development of novel pharmaceuticals and vaccines, and also contribute to fundamental understanding of mechanisms of cryo- and lyo-protection of proteins, viruses, and cells.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CNRS
INRA
ENSCL

Collections :

• Unité Matériaux et Transformations (UMET) - UMR 8207

Research team(s) :

Matériaux Moléculaires et Thérapeutiques

Submission date :

2022-01-28T09:16:49Z
2022-02-01T11:10:04Z