Title :

Prospective validation of a new imaging scorecard to assess leptomeningeal metastasis: a joint eortc btg and rano effort

Author(s) :

Le Rhun, Emilie [Auteur]
Devos, Patrick [Auteur]
Winklhofer, Sebastian [Auteur]
Lmalen, Hafida [Auteur]
Brandsma, Dieta [Auteur]
Kumthekar, Priya [Auteur]
Castellano, Antonella [Auteur]
Compter, Anette [Auteur]
Dhermain, Frederic [Auteur]
Franceschi, Enrico [Auteur]
Forsyth, Peter [Auteur]
Furtner, Julia [Auteur]
Galldiks, Norbert [Auteur]
Perez-Larraya, Jaime Gallego [Auteur]
Gempt, Jens [Auteur]
Hattingen, Elke [Auteur]
Hempel, Johann-Martin [Auteur]
Lukacova, Slavka [Auteur]
Minniti, Giuseppe [Auteur]
O'brien, Barbara [Auteur]
Postma, Tjeerd J. [Auteur]
Roth, Patrick [Auteur]
Ruda, Roberta [Auteur]
Schaefer, Niklas [Auteur]
Schmidt, Nils O. [Auteur]
Snijders, Tom J. [Auteur]
Thust, Steffi [Auteur]
Van Den Bent, Martin J. [Auteur]
Van Der Hoorn, Anouk [Auteur]
Vogin, Guillaume [Auteur]
Smits, Marion [Auteur]
Tonn, Joerg C. [Auteur]
Jaeckle, Kurt A. [Auteur]
Preusser, Matthias [Auteur]
Glantz, Michael [Auteur]
Wen, Patrick Y. [Auteur]
Bendszus, Martin [Auteur]
Weller, Michael [Auteur]

Journal title :

Neuro-Oncology

Abbreviated title :

Neuro Oncol

Publication date :

2022-02-14

ISSN :

1523-5866

Keyword(s) :

feasibility
MRI
response
brain
validation

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

BACKGROUND: Validation of the 2016 RANO MRI scorecard for leptomeningeal metastasis failed for multiple reasons. Accordingly, this joint EORTC Brain Tumor Group and RANO effort sought to prospectively validate a revised ...
Show more >BACKGROUND: Validation of the 2016 RANO MRI scorecard for leptomeningeal metastasis failed for multiple reasons. Accordingly, this joint EORTC Brain Tumor Group and RANO effort sought to prospectively validate a revised MRI scorecard for response assessment in leptomeningeal metastasis. METHODS: Coded paired cerebrospinal MRI of 20 patients with leptomeningeal metastases from solid cancers at baseline and follow-up after treatment and instructions for assessment were provided via the EORTC imaging platform. The Kappa coefficient was used to evaluate the inter-observer pairwise agreement. RESULTS: Thirty-five raters participated, including 9 neuroradiologists, 17 neurologists, 4 radiation oncologists, 3 neurosurgeons and 2 medical oncologists. Among single leptomeningeal metastases-related imaging findings at baseline, the best median concordance was noted for hydrocephalus (Kappa=0.63), and the worst median concordance for spinal linear enhancing disease (Kappa=0.46). The median concordance of raters for the overall response assessment was moderate (Kappa=0.44). Notably, the interobserver agreement for the presence of parenchymal brain metastases at baseline was fair (Kappa=0.29) and virtually absent for their response to treatment. 394 of 700 ratings (20 patients x 35 raters, 56%) were fully completed. In 308 of 394 fully completed ratings (78%), the overall response assessment perfectly matched the summary interpretation of the single ratings as proposed in the scorecard instructions. CONCLUSION: This study confirms the principle utility of the new scorecard, but also indicates the need for training of MRI assessment with a dedicated reviewer panel in clinical trials. Electronic case report forms with "blocking options" may be required to enforce completeness and quality of scoring.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

INSERM
Université de Lille

Collections :

• Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U1192

Submission date :

2022-06-15T14:00:58Z