Pharmacokinetics of Curative Tranexamic Acid in Parturients Undergoing Cesarean Delivery.

Gilliot, Sixtine; Ducloy-Bouthors, Anne-Sophie; Loingeville, Florence; Hennart, Benjamin; Allorge, Delphine; Lebuffe, Gilles; Odou, Pascal

Type de document :

Article dans une revue scientifique: Article original

DOI :

10.3390/pharmaceutics14030578

PMID :

35335955

URL permanente :

http://hdl.handle.net/20.500.12210/82430

Titre :

Pharmacokinetics of Curative Tranexamic Acid in Parturients Undergoing Cesarean Delivery.

Auteur(s) :

Gilliot, Sixtine [Auteur]
Groupe de Recherche sur les formes Injectables et les Technologies Associées (GRITA) - ULR 7365
Ducloy-Bouthors, Anne-Sophie [Auteur]
Hôpital Claude Huriez [Lille]
Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365 [GRITA]
Loingeville, Florence [Auteur]

METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Hennart, Benjamin [Auteur]

IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
Allorge, Delphine [Auteur]

IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
Lebuffe, Gilles [Auteur]

Groupe de Recherche sur les formes Injectables et les Technologies Associées (GRITA) - ULR 7365
Odou, Pascal [Auteur]

Groupe de Recherche sur les formes Injectables et les Technologies Associées (GRITA) - ULR 7365

Titre de la revue :

Pharmaceutics

Numéro :

Date de publication :

2022-03-27

ISSN :

1999-4923

Mot(s)-clé(s) :

tranexamic acid
postpartum hemorrhage
pharmacokinetics
intravenous
caesarean section

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

The aim of this study was to evaluate the population pharmacokinetics of tranexamic acid (TXA) administered intravenously at a single dose of 0.5 or 1 g in parturients undergoing active hemorrhagic cesarean delivery and ...
Lire la suite >The aim of this study was to evaluate the population pharmacokinetics of tranexamic acid (TXA) administered intravenously at a single dose of 0.5 or 1 g in parturients undergoing active hemorrhagic cesarean delivery and to evaluate the influence of patient variables on TXA pharmacokinetics. Subjects from three recruiting centers were included in this PK sub-study if randomized in the experimental group (i.v TXA 0.5 g or 1 g over one minute) of the TRACES study. Blood samples and two urinary samples were collected within 6 h after TXA injection. Parametric non-linear mixed-effect modeling (Monolix v2020R1) was computed. The final covariate model building used 315 blood and 117 urinary concentrations from seventy-nine patients. A two-compartment model with a double first-order elimination from the central compartment best described the data. The population estimates of clearance (CL), central volume of distribution (V1), and half-life for a typical 70 kg patient with an estimated renal clearance of 150 mL/min (Cockroft–Gault) were 0.14 L/h, 9.25 L, and 1.8 h. A correlation between estimated creatinine clearance and CL, body weight before pregnancy, and V1 was found and partly explained the PK variability. The final model was internally validated using a 500-run bootstrap. The first population pharmacokinetic model of TXA in active hemorrhagic caesarean section was successfully developed and internally validated. Keywords: caesarean section; intravenous; pharmacokinetics; postpartum hemoLire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
CHU Lille

Collections :

Groupe de Recherche sur les formes Injectables et les Technologies Associées (GRITA) - ULR 7365

Date de dépôt :

2023-05-25T02:43:15Z
2023-09-13T08:29:47Z

Historique des modifications

Numéro de version	Lien	Date de modification
3	20.500.12210/82430	2024-02-28T16:23:10Z
2	20.500.12210/82430.2*	2023-09-13T08:24:34Z
1	20.500.12210/82430.1	2023-05-25T02:43:15Z

*Version sélectionnée

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Pharmacokinetics of Curative Tranexamic ... BibTeX CSV Excel RIS

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Historique des modifications

Pharmacokinetics of Curative Tranexamic ...

BibTeX

CSV

Excel

RIS