Artificial enzymes, \"Chemzymes\": current ...
Document type :
Article dans une revue scientifique: Article de synthèse/Review paper
PMID :
Permalink :
Title :
Artificial enzymes, \"Chemzymes\": current state and perspectives
Author(s) :
Bjerre, Jeannette [Auteur]
University of Copenhagen = Københavns Universitet [UCPH]
Rousseau, Cyril [Auteur]
University of Copenhagen = Københavns Universitet [UCPH]
Unité de Catalyse et Chimie du Solide - UMR 8181 [UCCS]
Marinescu, Lavinia [Auteur]
University of Copenhagen = Københavns Universitet [UCPH]
Bols, Mikael [Auteur]
University of Copenhagen = Københavns Universitet [UCPH]
University of Copenhagen = Københavns Universitet [UCPH]
Rousseau, Cyril [Auteur]

University of Copenhagen = Københavns Universitet [UCPH]
Unité de Catalyse et Chimie du Solide - UMR 8181 [UCCS]
Marinescu, Lavinia [Auteur]
University of Copenhagen = Københavns Universitet [UCPH]
Bols, Mikael [Auteur]
University of Copenhagen = Københavns Universitet [UCPH]
Journal title :
Applied Microbiology and Biotechnology
Abbreviated title :
Appl. Microbiol. Biotechnol.
Volume number :
81
Pages :
1-11
Publication date :
2008-11-01
ISSN :
0175-7598
English keyword(s) :
Catalysis
Enzyme model
Biomimetic
Cyclodextrin
Supramolecular
Enzyme model
Biomimetic
Cyclodextrin
Supramolecular
HAL domain(s) :
Chimie
English abstract : [en]
Enzymes have fascinated scientists since their discovery and, over some decades, one aim in organic chemistry has been the creation of molecules that mimic the active sites of enzymes and promote catalysis. Nevertheless, ...
Show more >Enzymes have fascinated scientists since their discovery and, over some decades, one aim in organic chemistry has been the creation of molecules that mimic the active sites of enzymes and promote catalysis. Nevertheless, even today, there are relatively few examples of enzyme models that successfully perform Michaelis–Menten catalysis under enzymatic conditions (i.e., aqueous medium, neutral pH, ambient temperature) and for those that do, very high rate accelerations are seldomly seen. This review will provide a brief summary of the recent developments in artificial enzymes, so called “Chemzymes”, based on cyclodextrins and other molecules. Only the chemzymes that have shown enzyme-like activity that has been quantified by different methods will be mentioned. This review will summarize the work done in the field of artificial glycosidases, oxidases, epoxidases, and esterases, as well as chemzymes that catalyze conjugate additions, cycloadditions, and self-replicating processes. The focus will be mainly on cyclodextrin-based chemzymes since they have shown to be good candidate structures to base an enzyme model skeleton on. In addition hereto, other molecules that encompass binding properties will also be presented.Show less >
Show more >Enzymes have fascinated scientists since their discovery and, over some decades, one aim in organic chemistry has been the creation of molecules that mimic the active sites of enzymes and promote catalysis. Nevertheless, even today, there are relatively few examples of enzyme models that successfully perform Michaelis–Menten catalysis under enzymatic conditions (i.e., aqueous medium, neutral pH, ambient temperature) and for those that do, very high rate accelerations are seldomly seen. This review will provide a brief summary of the recent developments in artificial enzymes, so called “Chemzymes”, based on cyclodextrins and other molecules. Only the chemzymes that have shown enzyme-like activity that has been quantified by different methods will be mentioned. This review will summarize the work done in the field of artificial glycosidases, oxidases, epoxidases, and esterases, as well as chemzymes that catalyze conjugate additions, cycloadditions, and self-replicating processes. The focus will be mainly on cyclodextrin-based chemzymes since they have shown to be good candidate structures to base an enzyme model skeleton on. In addition hereto, other molecules that encompass binding properties will also be presented.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
Université de Lille
CNRS
Centrale Lille
ENSCL
Univ. Artois
CNRS
Centrale Lille
ENSCL
Univ. Artois
Collections :
Research team(s) :
Catalyse et chimie supramoléculaire (CASU)
Submission date :
2023-05-30T18:11:30Z
2024-04-24T11:08:03Z
2024-04-24T11:08:03Z