Artificial enzymes, \"Chemzymes\": current state and perspectives

Bjerre, Jeannette; Rousseau, Cyril; Marinescu, Lavinia; Bols, Mikael

Type de document :

Article dans une revue scientifique: Article de synthèse/Review paper

DOI :

10.1007/s00253-008-1653-5

PMID :

18787819

URL permanente :

http://hdl.handle.net/20.500.12210/83723

Titre :

Artificial enzymes, \"Chemzymes\": current state and perspectives

Auteur(s) :

Bjerre, Jeannette [Auteur]
University of Copenhagen = Københavns Universitet [UCPH]
Rousseau, Cyril [Auteur]

University of Copenhagen = Københavns Universitet [UCPH]
Unité de Catalyse et Chimie du Solide - UMR 8181 [UCCS]
Marinescu, Lavinia [Auteur]
University of Copenhagen = Københavns Universitet [UCPH]
Bols, Mikael [Auteur]
University of Copenhagen = Københavns Universitet [UCPH]

Titre de la revue :

Applied Microbiology and Biotechnology

Nom court de la revue :

Appl. Microbiol. Biotechnol.

Numéro :

Pagination :

1-11

Date de publication :

2008-11-01

ISSN :

0175-7598

Mot(s)-clé(s) en anglais :

Catalysis
Enzyme model
Biomimetic
Cyclodextrin
Supramolecular

Discipline(s) HAL :

Chimie

Résumé en anglais : [en]

Enzymes have fascinated scientists since their discovery and, over some decades, one aim in organic chemistry has been the creation of molecules that mimic the active sites of enzymes and promote catalysis. Nevertheless, ...
Lire la suite >Enzymes have fascinated scientists since their discovery and, over some decades, one aim in organic chemistry has been the creation of molecules that mimic the active sites of enzymes and promote catalysis. Nevertheless, even today, there are relatively few examples of enzyme models that successfully perform Michaelis–Menten catalysis under enzymatic conditions (i.e., aqueous medium, neutral pH, ambient temperature) and for those that do, very high rate accelerations are seldomly seen. This review will provide a brief summary of the recent developments in artificial enzymes, so called “Chemzymes”, based on cyclodextrins and other molecules. Only the chemzymes that have shown enzyme-like activity that has been quantified by different methods will be mentioned. This review will summarize the work done in the field of artificial glycosidases, oxidases, epoxidases, and esterases, as well as chemzymes that catalyze conjugate additions, cycloadditions, and self-replicating processes. The focus will be mainly on cyclodextrin-based chemzymes since they have shown to be good candidate structures to base an enzyme model skeleton on. In addition hereto, other molecules that encompass binding properties will also be presented.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
CNRS
Centrale Lille
ENSCL
Univ. Artois

Collections :

Unité de Catalyse et Chimie du Solide (UCCS) - UMR 8181

Équipe(s) de recherche :

Catalyse et chimie supramoléculaire (CASU)

Date de dépôt :

2023-05-30T18:11:30Z
2024-04-24T11:08:03Z

Numéro de version	Lien	Date de modification
2	20.500.12210/83723*	2024-04-24T11:05:25Z
1	20.500.12210/83723.1	2023-05-30T18:11:30Z

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Artificial enzymes, \"Chemzymes\": current ...

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