Title :

Pinning down signaling in the immune system: the role of the peptidyl-prolyl isomerase Pin1 in immune cell function.

Author(s) :

Esnault, Stéphane [Auteur]
University of Wisconsin School of Medicine and Public Health
Shen, Zong-Jian [Auteur]
University of Wisconsin School of Medicine and Public Health
Malter, James S [Auteur]
University of Wisconsin School of Medicine and Public Health

Journal title :

Critical Reviews in Immunology

Abbreviated title :

Crit Rev Immunol

Volume number :

28

Pages :

45-60

Publisher :

Begell House

Publication date :

2008-02-01

Article status :

Publié

ISSN :

1040-8401

English keyword(s) :

Animals
Apoptosis
B-Lymphocytes
Cytokines
Immune System
Peptidylprolyl Isomerase
Signal Transduction
T-Lymphocytes
Tacrolimus Binding Proteins

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

The peptidyl prolyl isomerase (PPIase) Pin1 has been recently implicated in cell cycle control and neuropathologies. There is now growing evidence that Pin1 plays an important role in the immune system and does so ...
Show more >The peptidyl prolyl isomerase (PPIase) Pin1 has been recently implicated in cell cycle control and neuropathologies. There is now growing evidence that Pin1 plays an important role in the immune system and does so differentially from the related PPIases, cyclophilinA and FKBP. This review describes how Pin1 modulates cytokine expression by activated T cells and eosinophils and participates in T-cell and eosinophil apoptotic decisions both in vitro and in vivo. We highlight several possible immunologic diseases, including asthma, as well as organ transplant rejection, where anti-Pin1 therapeutics maybe of value.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Autres travaux scientifiques

Submission date :

2023-11-14T11:08:15Z
2024-05-30T12:50:32Z