Title :

Dietary inflammatory index, risk of incident hypertension, and effect modification from BMI.

Author(s) :

Macdonald, Conor-James [Auteur]
Centre de recherche en épidémiologie et santé des populations [CESP]
Laouali, Nasser [Auteur]
Centre de recherche en épidémiologie et santé des populations [CESP]
Mode de vie, génétique et santé : études intégratives et transgénérationnelles [U1018 (Équipe 9)]
Madika, Anne-Laure [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Mancini, Francesca Romana [Auteur]
Centre de recherche en épidémiologie et santé des populations [CESP]
Boutron-Ruault, Marie-Christine [Auteur]
Centre de recherche en épidémiologie et santé des populations [CESP]

Journal title :

Nutrition Journal

Abbreviated title :

Nutr J

Volume number :

19

Pages :

62

Publication date :

2020-06-27

ISSN :

1475-2891

English keyword(s) :

Inflammation
Dietary inflammatory index
Hypertension
Nutrition
Epidemiology

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Introduction Previous studies have identified a positive association between the inflammatory potential of the diet and hypertension. It is not known if BMI is an effect modifier for this association, nor if the association ...
Show more >Introduction Previous studies have identified a positive association between the inflammatory potential of the diet and hypertension. It is not known if BMI is an effect modifier for this association, nor if the association is dose-respondent. This study aimed to assess the association between the dietary inflammatory index (DII) and the risk of hypertension, and assess any effect modification from BMI. Methods Data from the E3N cohort study, a French prospective population-based study initiated in 1990 was used. From the women in the study, we included those who completed a detailed diet history questionnaire, and who did not have prevalent hypertension or cardiovascular disease at baseline, resulting in 46,652 women. The adapted DII was assessed with data from the dietary questionnaire. Hypertension cases were self-reported and verified through a drug-reimbursement database. Cox proportional hazard models were used to calculate hazard ratios. Spline regression was used to determine any dose-respondent relationship. Results During 884,267 person-years, 13,183 cases of incident hypertension were identified. The median DII in the population was slightly pro-inflammatory (DII = + 0.44). A highly pro-inflammatory diet (DII >  3.0) was associated with a slight increase in hypertension risk (HRQ1-Q5 = 1.07 [1.02, 1.13]). Evidence was observed for effect modification from BMI, with associations strongest amongst women in the 18.5–21.0 BMI range (HRQ1-Q5 = 1.17 [1.06, 1.29]). A weak dose-respondent relationship was observed. Conclusion Evidence for a weak association between DII and hypertension was observed. Associations were stronger amongst healthy-lean women.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CHU Lille

Collections :

• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Submission date :

2023-11-15T08:38:40Z
2024-01-08T09:15:51Z