Titre :

Clinical and immunological spectra of human cutaneous leishmaniasis in North Africa and French Guiana

Auteur(s) :

Saidi, Nasreddine [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Blaizot, Romain [Auteur]
Prévot, Ghislaine [Auteur]
Biomes Tropicaux et Immuno-Pathophysiologie = Tropical Biome and ImmunoPhysiopathology [Lille] [TBIP]
Aoun, Karim [Auteur]
Institut Pasteur de Tunis
Demar, Magalie [Auteur]
Biomes Tropicaux et Immuno-Pathophysiologie = Tropical Biome and ImmunoPhysiopathology [Lille] [TBIP]
Cazenave, Pierre André [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Bouratbine, Aida [Auteur]
Institut Pasteur de Tunis
Pied, Sylviane [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]

Titre de la revue :

Frontiers in Immunology

Éditeur :

Frontiers

Date de publication :

2023-07-27

ISSN :

1664-3224

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Cutaneous leishmaniasis (CL) caused by infection with the parasite Leishmania exhibits a large spectrum of clinical manifestations ranging from single healing to severe chronic lesions with the manifestation of resistance ...
Lire la suite >Cutaneous leishmaniasis (CL) caused by infection with the parasite Leishmania exhibits a large spectrum of clinical manifestations ranging from single healing to severe chronic lesions with the manifestation of resistance or not to treatment. Depending on the specie and multiple environmental parameters, the evolution of lesions is determined by a complex interaction between parasite factors and the early immune responses triggered, including innate and adaptive mechanisms. Moreover, lesion resolution requires parasite control as well as modulation of the pathologic local inflammation responses and the initiation of wound healing responses. Here, we have summarized recent advances in understanding the in situ immune response to cutaneous leishmaniasis: i ) in North Africa caused by Leishmania (L.) major , L. tropica , and L. infantum , which caused in most cases localized autoresolutives forms, and ii ) in French Guiana resulting from L. guyanensis and L. braziliensis , two of the most prevalent strains that may induce potentially mucosal forms of the disease. This review will allow a better understanding of local immune parameters, including cellular and cytokines release in the lesion, that controls infection and/or protect against the pathogenesis in new world compared to old world CL.Lire moins >

Langue :

Anglais

Comité de lecture :

Oui

Audience :

Internationale

Vulgarisation :

Non

Projet ANR :

Alliance française contre les maladies parasitaires

Collections :

• Centre d'Infection et d'Immunité de Lille (CIIL) - U1019 - UMR 9017

Source :

Harvested from HAL