Titre :

Real-World Data on Newly Diagnosed <i>BRCA</i>-Mutated High-Grade Epithelial Ovarian Cancers: The French National Multicenter ESME Database.

Auteur(s) :

Bini, M. [Auteur]
Centre Léon Bérard [Lyon]
Quesada, S. [Auteur]
Centre Léon Bérard [Lyon]
Institut de Recherche en Cancérologie de Montpellier [IRCM - U1194 Inserm - UM]
Meeus, P. [Auteur]
Centre Léon Bérard [Lyon]
Rodrigues, M. [Auteur]
Institut Curie [Paris]
Leblanc, Eric [Auteur]
Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U1192
Floquet, A. [Auteur]
Institut Bergonié [Bordeaux]
Pautier, P. [Auteur]
Institut Gustave Roussy [IGR]
Marchal, F. [Auteur]
Institut de Cancérologie de Lorraine - Alexis Vautrin [Nancy] [UNICANCER/ICL]
Provansal, M. [Auteur]
Institut Paoli-Calmettes [IPC]
Campion, L. [Auteur]
Institut de Cancérologie de l'Ouest [Angers/Nantes] [UNICANCER/ICO]
Causeret, S. [Auteur]
Gourgou, S. [Auteur]
Ray-Coquard, I. [Auteur]
Classe, J. M. [Auteur]
Pomel, C. [Auteur]
Centre Jean Perrin [Clermont-Ferrand] [UNICANCER/CJP]
De La Motte Rouge, T. [Auteur]
Barranger, E. [Auteur]
Savoye, A. M. [Auteur]
Guillemet, C. [Auteur]
Gladieff, L. [Auteur]
Demarchi, M. [Auteur]
Rouzier, R. [Auteur]
Courtinard, C. [Auteur]
Romeo, C. [Auteur]
Joly, F. [Auteur]

Titre de la revue :

Cancers

Nom court de la revue :

Cancers (Basel)

Numéro :

14

Date de publication :

2022-08-28

ISSN :

2072-6694

Mot(s)-clé(s) en anglais :

BRCA1
BRCA2
high-grade epithelial ovarian cancer
real-world data
epidemiology
overall survival
platinum-based chemotherapy
progression-free survival
treatment patterns
epidemiological strategy and medical economics database

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Background: In spite of the frequency and clinical impact of BRCA1/2 alterations in high-grade epithelial ovarian cancer (HGEOC), real-world information based on robust data warehouse has been scarce to date. Methods: ...
Lire la suite >Background: In spite of the frequency and clinical impact of BRCA1/2 alterations in high-grade epithelial ovarian cancer (HGEOC), real-world information based on robust data warehouse has been scarce to date. Methods: Consecutive patients with BRCA-mutated HGEOC treated between 2011 and 2016 within French comprehensive cancer centers from the Unicancer network were extracted from the ESME database. The main objective of the study was the assessment of clinicopathological and treatments parameters. Results: Out of the 8021 patients included in the ESME database, 266 patients matching the selection criteria were included. BRCA1 mutation was found in 191 (71.8%) patients, while 75 (28.2%) had a BRCA2 mutation only; 95.5% of patients received a cytoreductive surgery. All patients received a taxane/platinum-based chemotherapy (median = six cycles). Complete and partial response were obtained in 53.3% and 20.4% of the cases, respectively. Maintenance therapy was administered in 55.3% of the cases, bevacizumab being the most common agent. After a median follow up of 51.7 months, a median progression-free survival of 28.6 months (95% confidence interval (CI) [26.5; 32.7]) and an estimated 5-year median overall survival of 69.2% (95% CI [61.6; 70.3]) were reported. Notably, BRCA1- and BRCA2-mutated cases exhibited a trend towards different median progression-free survivals, with 28.0 (95% CI [24.4; 32.3]) and 33.3 months (95% CI [26.7; 46.1]), respectively (p-value = 0.053). Furthermore, five-year OS for BRCA1-mutated patients was 64.5% (95% CI [59.7; 69.2]), while it was 82.5% (95% CI [76.6; 88.5]) for BRCA2-mutated ones (p-value = 0.029). Conclusions: This study reports the largest French multicenter cohort of BRCA-mutated HGEOCs based on robust data from the ESME, exhibiting relevant real-world data regarding this specific population.Lire moins >

Comité de lecture :

Oui

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U1192

Date de dépôt :

2023-12-13T04:09:13Z
2024-01-23T15:48:29Z