Titre :

Outcome of autosomal dominant polycystic kidney disease patients on peritoneal dialysis: a national retrospective study based on two French registries (the French Language Peritoneal Dialysis Registry and the French Renal Epidemiology and Information Network).

Auteur(s) :

Sigogne, Mickael [Auteur]
Kanagaratnam, Lukshe [Auteur]
Dupont, Vincent [Auteur]
Recherche Interdisciplinaire en Management et Économie Lab - ULR 7396 [RIME-Lab]
Couchoud, Cecile [Auteur]
Verger, Christian [Auteur]
Maheut, Herve [Auteur]
Hazzan, Marc [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Halimi, Jean-Michel [Auteur]
Barbe, Coralie [Auteur]
Canivet, Eric [Auteur]
Petrache, Andreea [Auteur]
Drame, Moustapha [Auteur]
Rieu, Philippe [Auteur]
Matrice Extracellulaire et Dynamique Cellulaire - UMR CNRS 7369 [MEDyC]
Toure, Fatouma [Auteur]
Matrice Extracellulaire et Dynamique Cellulaire - UMR CNRS 7369 [MEDyC]

Titre de la revue :

Nephrology Dialysis Transplantation

Nom court de la revue :

Nephrol. Dial. Transplant.

Numéro :

33

Pagination :

2020–2026

Éditeur :

Oxford University Press

Date de publication :

2018-11

ISSN :

1460-2385

Mot(s)-clé(s) :

peritoneal dialysis
ADPKD
chronic hemodialysis
technical survival
patient survival

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Background: Pathological features of autosomal dominant polycystic kidney disease (ADPKD) include enlarged kidney volume, higher frequency of digestive diverticulitis and abdominal wall hernias. Therefore, many nephrologists ...
Lire la suite >Background: Pathological features of autosomal dominant polycystic kidney disease (ADPKD) include enlarged kidney volume, higher frequency of digestive diverticulitis and abdominal wall hernias. Therefore, many nephrologists have concerns about the use of peritoneal dialysis (PD) in ADPKD patients. We aimed to analyse survival and technique failure in ADPKD patients treated with PD. Methods: We conducted two retrospective studies on patients starting dialysis between 2000 and 2010. We used two French registries: the French Renal Epidemiology and Information Network (REIN) and the French language Peritoneal Dialysis Registry (RDPLF). Using the REIN registry, we compared the clinical features and outcomes of ADPKD patients on PD (n = 638) with those of ADPKD patients on haemodialysis (HD) (n = 4653); with the RDPLF registry, those same parameters were determined for ADPKD patients on PD (n = 797) and compared with those of non-ADPKD patients on PD (n = 12 059). Results: A total of 5291 ADPKD patients and 12 059 non-ADPKD patients were included. Analysis of the REIN registry found that ADPKD patients treated with PD represented 10.91% of the ADPKD population. During the study period, PD was used for 11.2% of the non-ADPKD population. Compared with ADPKD patients on HD, ADPKD patients on PD had higher serum albumin levels (38.8 ± 5.3 versus 36.8 ± 5.7 g/dL, P < 0.0001) and were less frequently diabetic (5.31 versus 7.71%, P < 0.03). The use of PD in ADPKD patients was positively associated with the occurrence of a kidney transplantation but not with death [hazard ratio 1.15 (95% confidence interval 0.84–1.58)]. Analysis of the RDPLF registry found that compared with non-ADPKD patients on PD, ADPKD patients on PD were younger and had fewer comorbidities and better survival. ADPKD status was not associated with an increased risk of technique failure or an increased risk of peritonitis. Conclusions: According to our results, PD is proposed to a selected population of ADPKD patients, PD does not have a negative impact on ADPKD patients’ overall survival and PD technique failure is not influenced by ADPKD status. Therefore PD is a reasonable option for ADPKD patients.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Inserm
Université de Lille
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
• Recherche Interdisciplinaire en Management et Économie Lab (RIME-Lab) - ULR 7396

Équipe(s) de recherche :

Immunity, inflammation and fibrsis in auto and allo-reactivity

Date de dépôt :

2019-03-01T14:46:27Z
2023-12-01T13:31:03Z
2023-12-13T14:23:54Z