Title :

Anxiety in Parkinson's Disease Is Associated with Changes in Brain Structural Connectivity.

Author(s) :

Carey, Guillaume [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Viard, Romain [Auteur]
Plateformes Lilloises en Biologie et Santé - UAR 2014 - US 41 [PLBS]
Lopes, Renaud [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Plateformes Lilloises en Biologie et Santé - UAR 2014 - US 41 [PLBS]
Kuchcinski, Gregory [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Plateformes Lilloises en Biologie et Santé - UAR 2014 - US 41 [PLBS]
DEFEBVRE, Luc [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Leentjens, A. F. G. [Auteur]
Dujardin, Kathy [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]

Journal title :

Journal of Parkinson's disease

Abbreviated title :

J Parkinsons Dis

Volume number :

13

Pages :

p. 989-998

Publication date :

2023

ISSN :

1877-718X

English keyword(s) :

White matter
diffusion tensor imaging
fiber track
tractometry
basal ganglia
anxiety-related circuits

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Background: Anxiety in Parkinson’s disease (PD) has been associated with grey matter changes and functional changes in anxiety-related neuronal circuits. So far, no study has analyzed white matter (WM) changes in patients ...
Show more >Background: Anxiety in Parkinson’s disease (PD) has been associated with grey matter changes and functional changes in anxiety-related neuronal circuits. So far, no study has analyzed white matter (WM) changes in patients with PD and anxiety. Objective: The aim of this study was to identify WM changes by comparing PD patients with and without anxiety, using diffusion-tensor imaging (DTI). Methods: 108 non-demented PD patients with (n = 31) and without (n = 77) anxiety as defined by their score on the Parkinson Anxiety Scale participated. DTI was used to determine the fractional anisotropy (FA) and mean diffusivity (MD) in specific tracts within anxiety-related neuronal circuits. Mean FA and MD were compared between groups and correlated with the severity of anxiety adjusted by sex, center, Hoehn & Yahr stage, levodopa equivalent daily dosage, and Hamilton depression rating scale. Results: Compared to patients without anxiety, PD patients with anxiety showed lower FA within the striato-orbitofrontal, striato-cingulate, cingulate-limbic, and caudate-thalamic tracts; higher FA within the striato-limbic and accumbens-thalamic tracts; higher MD within the striato-thalamic tract and lower MD within the striato-limbic tract. Conclusions: Anxiety in PD is associated with microstructural alterations in anxiety-related neuronal circuits within the WM. This result reinforces the view that PD-related anxiety is linked to structural alteration within the anxiety-related brain circuits.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172
• Plateformes Lilloises en Biologie et Santé (PLBS) - UAR 2014 - US 41

Submission date :

2023-12-21T06:33:55Z
2024-01-28T06:15:44Z