Title :

Structure of the decoy module of human glycoprotein 2 and uromodulin and its interaction with bacterial adhesin FimH

Author(s) :

Stsiapanava, A. [Auteur]
Xu, C. R. [Auteur]
Nishio, S. [Auteur]
Han, L. [Auteur]
Yamakawa, Nao [Auteur]
Plateformes Lilloises en Biologie et Santé - UAR 2014 - US 41 [PLBS]
Carroni, M. [Auteur]
Tunyasuvunakool, K. [Auteur]
Jumper, J. [Auteur]
De Sanctis, D. [Auteur]
Wu, B. [Auteur]
Jovine, L. [Auteur]

Journal title :

Nature Structural and Molecular Biology

Abbreviated title :

Nat. Struct. Mol. Biol.

Volume number :

29

Pages :

190-193

Publication date :

2023-03-10

ISSN :

1545-9993

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Glycoprotein 2 (GP2) and uromodulin (UMOD) filaments protect against gastrointestinal and urinary tract infections by acting as decoys for bacterial fimbrial lectin FimH. By combining AlphaFold2 predictions with X-ray ...
Show more >Glycoprotein 2 (GP2) and uromodulin (UMOD) filaments protect against gastrointestinal and urinary tract infections by acting as decoys for bacterial fimbrial lectin FimH. By combining AlphaFold2 predictions with X-ray crystallography and cryo-EM, we show that these proteins contain a bipartite decoy module whose new fold presents the high-mannose glycan recognized by FimH. The structure rationalizes UMOD mutations associated with kidney diseases and visualizes a key epitope implicated in cast nephropathy.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Collections :

• Plateformes Lilloises en Biologie et Santé (PLBS) - UAR 2014 - US 41

Submission date :

2023-12-21T07:02:17Z
2024-02-23T10:14:06Z