Titre :

Proteomic biomarkers for survival in systemic sclerosis-associated pulmonary hypertension.

Auteur(s) :

Mismetti, Valentine [Auteur]
Santé Ingénierie Biologie Saint-Etienne [SAINBIOSE]
Delavenne, Xavier [Auteur]
Santé Ingénierie Biologie Saint-Etienne [SAINBIOSE]
Montani, David [Auteur]
Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre]
Hypertension pulmonaire : physiopathologie et innovation thérapeutique [HPPIT]
Bezzeghoud, Souad [Auteur]
Centre d'Investigation Clinique - Epidémiologie Clinique [CHU Saint-Etienne] [CIC-EC 1408]
Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] [CHU ST-E]
Delezay, Olivier [Auteur]
Université Jean Monnet - Saint-Étienne [UJM]
Santé Ingénierie Biologie Saint-Etienne [SAINBIOSE]
Hodin, Sophie [Auteur]
Santé Ingénierie Biologie Saint-Etienne [SAINBIOSE]
Launay, David [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Marchand-Adam, Sylvain [Auteur]
Centre Hospitalier Régional Universitaire de Tours [CHRU Tours]
Nunes, Hilario [Auteur]
Hôpital Avicenne [AP-HP]
Hypoxie et Poumon : pneumopathologies fibrosantes, modulations ventilatoires et circulatoires [H&P - U1272 Inserm]
Ollier, Edouard [Auteur]
Santé Ingénierie Biologie Saint-Etienne [SAINBIOSE]
Reynaud-Gaubert, Martine [Auteur]
Hôpital Nord [CHU - APHM]
Pastre, Jean [Auteur]
Hôpital Européen Georges Pompidou [APHP] [HEGP]
Traclet, Julie [Auteur]
Hôpital Louis Pradel [CHU - HCL]
Centre national de référence des maladies pulmonaires rares [Lyon] [CRMPM]
Quetant, Sébastien [Auteur]
Centre Hospitalier Universitaire [CHU Grenoble] [CHUGA]
Zeghmar, Sabrina [Auteur]
Hôpital Louis Pradel [CHU - HCL]
Bertoletti, Laurent [Auteur]
Centre d'Investigation Clinique - Epidémiologie Clinique [CHU Saint-Etienne] [CIC-EC 1408]
Santé Ingénierie Biologie Saint-Etienne [SAINBIOSE]
Cottin, Vincent [Auteur]
Université Claude Bernard Lyon 1 [UCBL]
Hôpital Louis Pradel [CHU - HCL]
Infections Virales et Pathologie Comparée - UMR 754 [IVPC]
Centre national de référence des maladies pulmonaires rares [Lyon] [CRMPM]

Titre de la revue :

Respiratory Research

Nom court de la revue :

Respir Res

Numéro :

24

Pagination :

273

Date de publication :

2023-11-09

ISSN :

1465-993X

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Background Interstitial lung disease (ILD) and pulmonary hypertension (PH) represent the major causes of mortality in systemic sclerosis (SSc). Patients with systemic sclerosis and combined PH and ILD (SSc-PH-ILD) generally ...
Lire la suite >Background Interstitial lung disease (ILD) and pulmonary hypertension (PH) represent the major causes of mortality in systemic sclerosis (SSc). Patients with systemic sclerosis and combined PH and ILD (SSc-PH-ILD) generally have a poor prognosis. Predictors of survival and of potential benefit of treatment are lacking in patients with SSc-PH-ILD. Objective To identify specific plasma protein expression patterns associated with survival in patients with SSc-PH-ILD. Materials and methods Post-hoc analysis of a prospective multicenter French study in patients with PH-ILD. An untargeted proteomic analysis using mass spectrometry was performed to identify plasma protein changes associated with long-term overall survival in patients with SSc-PH-ILD. Results Thirty two patients were included in the analysis, of whom 13 died during follow-up (median survival: 76.5 months). At baseline, survivors had less severe hemodynamic impairment [pulmonary vascular resistance of 4.4 Wood Units (IQR 3–5.2) vs. 6.2 Wood Units (IQR 4.2–10.7)] and higher carbon monoxide diffusing capacity [median 39% (IQR 35–44%) vs. 25% (IQR 22–30.5%)], than the 13 patients who died. Seven proteins, associated with haemostasis and fibrosis, were differentially expressed according to patients’ survival. In the survivor group, two proteins were increased (ADAMTS13, SERPIND1) and five were decreased (PTGDS, OLFM1, C7, IGFBP7, FBN1) compared to the non-survivor groups. Conclusion The prognosis of SSc-PH-ILD patients is poor. This proteomic approach found 7 plasma proteins (involved in haemostasis and fibrosis pathways) associated with survival. These potential biomarkers may be good candidates to prognostic enrichment.Lire moins >

Langue :

Anglais

Comité de lecture :

Oui

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Date de dépôt :

2024-01-11T22:06:02Z
2024-03-08T10:56:06Z