Title :

Transfused Red Blood Cell Characteristics and Kidney Transplant Outcomes Among Patients Receiving Early Posttransplant Transfusion.

Author(s) :

Gaiffe, Emilie [Auteur]
Centre Hospitalier Régional Universitaire de Besançon [CHRU Besançon]
Vernerey, Dewi [Auteur]
Centre Hospitalier Régional Universitaire de Besançon [CHRU Besançon]
Bardiaux, Laurent [Auteur]
Etablissement français du sang [Pyrénées-Méditerranée] [EFS Pyrénées-Méditerranée]
Leroux, Franck [Auteur]
Centre Hospitalier Régional Universitaire de Besançon [CHRU Besançon]
Meurisse, Aurélia [Auteur]
Centre Hospitalier Régional Universitaire de Besançon [CHRU Besançon]
Bamoulid, Jamal [Auteur]
Centre Hospitalier Régional Universitaire de Besançon [CHRU Besançon]
Courivaud, Cecile [Auteur]
Centre Hospitalier Régional Universitaire de Besançon [CHRU Besançon]
Saas, Philippe [Auteur]
Centre Hospitalier Régional Universitaire de Besançon [CHRU Besançon]
Hazzan, Marc [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Tiberghien, Pierre [Auteur]
Etablissement Français du Sang Provence-Alpes Côte-d'Azur et Corse [EFS]
Centre Hospitalier Régional Universitaire de Besançon [CHRU Besançon]
Ducloux, Didier [Auteur]
Centre Hospitalier Régional Universitaire de Besançon [CHRU Besançon]

Journal title :

JAMA Network Open

Abbreviated title :

JAMA Netw Open

Volume number :

6

Pages :

e2332821

Publication date :

2023-09-15

ISSN :

2574-3805

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Importance Red blood cell transfusion (RBCT) is frequently required in the early post–kidney transplant period, but long-term outcomes associated with RBCT is controversial. Therefore, it may be relevant to investigate ...
Show more >Importance Red blood cell transfusion (RBCT) is frequently required in the early post–kidney transplant period, but long-term outcomes associated with RBCT is controversial. Therefore, it may be relevant to investigate the association between RBCT characteristics and transplant outcomes. Objective To study the association between RBC storage duration and transplant outcomes. Design, Setting, and Participants This was a nationwide retrospective cohort study based on data linking between 2 prospective French nationwide registries. Clinical transplant parameters, outcomes, and RBCT characteristics were extracted from the CRISTAL registry of the Agence de la Biomédecine and the national database of the Etablissement Français du Sang. All 12 559 patients having received a first kidney transplant in France between January 1, 2002, and December 31, 2008, were included. Patients were followed up from transplant to graft loss, death with a functional graft, or data retrieval in June 2016. Data were analyzed from April 2019 to June 2022. Exposures Clinical outcomes of transplant recipients who underwent early RBCT were analyzed considering transfusion characteristics. Main Outcomes and Measures Cox proportional hazards regression models were fitted to evaluate transplant failure defined as graft loss or death with a functional graft. Results Among 12 559 patients who underwent kidney transplant, 3483 received an RBCT during the first 14 days posttransplant. The median (IQR) age of patients was 53.0 (41.5-61.2) years, and 1929 patients (55.4%) were male. Median (IQR) follow-up was 7.8 (7.6-8.0) years. In multivariable analysis, longer (vs shorter) storage duration of transfused RBC was associated with a decrease in risk of transplant failure (hazard ratio, 0.99; 95% CI, 0.98-1.00 for each additional storage day; P = .06). Patients transfused with at least 1 RBC unit stored for more than 20 days had a 5% absolute decrease in transplant failure at 3 years and 7% at 5 years compared with those who received RBC stored for less than 20 days. Conclusions and Relevance In this study, longer RBC storage duration was associated with a decreased risk of transplant failure among patients who received kidney transplants and RBC transfusions. Preferential use of RBC with longer storage duration might improve kidney graft survival following transplant and transfusion.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2024-01-11T22:13:30Z
2024-03-05T14:54:05Z