Title :

Preoperative Predictors of Neoplasia in Patients Undergoing Small Bowel Resection for Complicated Crohn's Disease: A Multicentre Case-Control Study.

Author(s) :

Chappe, Capucine [Auteur]
Université de Bordeaux [UB]
Salut, Cecile [Auteur]
Hôpital Haut-Lévêque [CHU Bordeaux]
Centre Hospitalier Universitaire de Bordeaux [CHU Bordeaux]
Amiot, Aurelien [Auteur]

Gaye, Delphine [Auteur]
Hôpital Haut-Lévêque [CHU Bordeaux]
Frulio, Nora [Auteur]
Hôpital Haut-Lévêque [CHU Bordeaux]
Lapuyade, Bruno [Auteur]
Hôpital Haut-Lévêque [CHU Bordeaux]
Vuitton, Lucine [Auteur]
Centre Hospitalier Régional Universitaire de Besançon [CHRU Besançon]
Altwegg, Romain [Auteur]
Hôpital Saint Eloi [CHU Montpellier]
Gilletta, Cyrielle [Auteur]
Centre Hospitalier Universitaire de Toulouse [CHU Toulouse]
Fumery, Mathurin [Auteur]
CHU Amiens-Picardie
Bouguen, Guillaume [Auteur]
Centre Hospitalier Universitaire [Rennes]
Serrero, Melanie [Auteur]
CHU Marseille
Nachury, Maria [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
De Suray, Nicolas [Auteur]
Centre Hospitalier Universitaire de Charleroi-Chimay [CHU Charleroi]
Caillo, Ludovic [Auteur]
Centre Hospitalier Universitaire de Nîmes [CHU Nîmes]
Simon, Mireille [Auteur]
Centre hospitalier de Pau
Laharie, David [Auteur]
Centre Hospitalier Universitaire de Bordeaux [CHU Bordeaux]
Rivière, Pauline [Auteur]
Centre Hospitalier Universitaire de Bordeaux [CHU Bordeaux]
Poullenot, Florian [Auteur]
Centre Hospitalier Universitaire de Bordeaux [CHU Bordeaux]

Journal title :

Cancers (Basel)

Abbreviated title :

Cancers (Basel)

Volume number :

15

Publication date :

2023-04-14

ISSN :

2072-6694

English keyword(s) :

Crohn's disease
small bowel neoplasia
predictive factors
small bowel adenocarcinoma

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Crohn's disease (CD) is associated with an increased risk of small bowel neoplasia (SBN). We aimed to assess preoperative predictors of SBN in CD patients. We conducted a retrospective case-control study including CD ...
Show more >Crohn's disease (CD) is associated with an increased risk of small bowel neoplasia (SBN). We aimed to assess preoperative predictors of SBN in CD patients. We conducted a retrospective case-control study including CD patients who underwent surgery: cases were diagnosed with SBN on histopathological analysis and controls had no neoplasia. Preoperative cross-sectional imaging was reviewed by a panel of blinded expert radiologists. Fifty cases were matched to one hundred and fifty consecutive controls. In multivariable analysis, predictors of SBN were age ≥ 50 years (OR = 28, 95% CI = 5.05-206), median CD duration ≥ 17.5 years (OR = 4.25, 95% CI = 1.33-14.3), and surgery for stricture (OR = 5.84, 95% CI = 1.27-35.4). The predictors of small bowel adenocarcinoma were age ≥ 50 years (OR = 5.14, 95% CI = 2.12-12.7), CD duration ≥ 15 years (OR = 5.65, 95% CI = 2.33-14.3), and digestive wall thickening > 8 mm (OR = 3.79, 95% CI = 1.45-11.3). A predictive score based on the aforementioned factors was constructed. Almost 73.7% of patients with a high score had SBA. Old age, long small bowel CD duration, and stricture predicted the presence of SBN, particularly adenocarcinoma when patients have digestive wall thickening > 8 mm on preoperative imaging.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2024-01-11T23:00:20Z
2024-03-25T14:59:14Z