Title :

Autologous versus allogeneic hematopoietic cell transplantation for older patients with acute lymphoblastic leukemia. An analysis from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation.

Author(s) :

Giebel, Sebastian [Auteur]
Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology [MCMCC]
Labopin, Myriam [Auteur]
CHU Saint-Antoine [AP-HP]
Houhou, Mohamed [Auteur]
CHU Saint-Antoine [AP-HP]
Caillot, Denis [Auteur]
CHU Dijon
Finke, Jürgen [Auteur]
University of Freiburg [Freiburg]
Blaise, Didier [Auteur]
Institut Paoli-Calmettes [IPC]
Fegueux, Nathalie [Auteur]
Hôpital Lapeyronie [Montpellier] [CHU]
Ethell, Mark [Auteur]
The Royal Marsden
Cornelissen, Jan J. [Auteur]
Erasmus University Medical Center [Rotterdam] [Erasmus MC]
Forcade, Edouard [Auteur]
CHU Bordeaux
Yakoub-Agha, Ibrahim [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Lussana, Federico [Auteur]
Università degli Studi di Bergamo = University of Bergamo [UniBg]
Maertens, Johan [Auteur]
University Hospital Gasthuisberg [Leuven]
Bourhis, Jean-Henri [Auteur]
Institut Gustave Roussy [IGR]
Jindra, Pavel [Auteur]
Gorin, Norbert Claude [Auteur]
CHU Saint-Antoine [AP-HP]
Nagler, Arnon [Auteur]
Chaim Sheba Medical Center
Mohty, Mohamad [Auteur]
CHU Saint-Antoine [AP-HP]

Journal title :

Bone Marrow Transplantation

Abbreviated title :

Bone Marrow Transplant

Publication date :

2023-01-09

ISSN :

1476-5365

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Allogeneic hematopoietic cell transplantation (allo-HCT) with reduced intensity conditioning (RIC) is an option for elderly patients with acute lymphoblastic leukemia (ALL). We retrospectively compared results of RIC-allo-HCT ...
Show more >Allogeneic hematopoietic cell transplantation (allo-HCT) with reduced intensity conditioning (RIC) is an option for elderly patients with acute lymphoblastic leukemia (ALL). We retrospectively compared results of RIC-allo-HCT from either a matched sibling donor (MSD, n = 209) or matched unrelated donor (MUD, n = 209) with autologous (auto, n = 142) HCT for patients aged 55 years or more treated in first complete remission (CR1) between 2000 and 2018. The probabilities of leukemia-free survival (LFS) at 5 years were 34% for RIC-allo-HCT versus 39% for auto-HCT (p = 0.11) while overall survival (OS) rates were 42% versus 45% (p = 0.23), respectively. The incidence of relapse (RI) and non-relapse mortality (NRM) was 41% versus 51% (p = 0.22) and 25% versus 10% (p = 0.001), respectively. In a multivariate model, using auto-HCT as reference, the risk of NRM was increased for MSD-HCT (Hazard ratio [HR] = 2.1, p = 0.02) and MUD-HCT (HR = 3.08, p < 0.001), which for MUD-HCT translated into a decreased chance of LFS (HR = 1.55, p = 0.01) and OS (HR = 1.62, p = 0.008). No significant associations were found with respect to the risk of relapse. We conclude that for patients with ALL in CR1, aged above 55 years, auto-HCT may be considered a transplant option alternative to RIC-allo-HCT, although its value requires verification in prospective trials.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2024-01-11T23:42:42Z
2024-02-27T14:42:47Z