Title :

Starch-based NP act as antigen delivery systems without immunomodulating effect.

Author(s) :

Fasquelle, Francois [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Dubuquoy, Laurent [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Betbeder, Didier [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Journal title :

PLoS ONE

Abbreviated title :

PLoS One

Volume number :

17

Pages :

e0272234

Publication date :

2023-04-04

ISSN :

1932-6203

English keyword(s) :

Antigen encapsulation
Epithelial cells
Secretion
Immune response
Antigens
Cytokines
Endocytosis
Nanoparticles

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

The nasal route of immunization has become a real alternative to injections. It is indeed described as more efficient at inducing immune protection, since it initiates both mucosal and systemic immunity, thus protecting ...
Show more >The nasal route of immunization has become a real alternative to injections. It is indeed described as more efficient at inducing immune protection, since it initiates both mucosal and systemic immunity, thus protecting against both the infection itself and the transmission of pathogens by the host. However, the use of immunomodulators should be limited since they induce inflammation. Here we investigated in vitro the mechanisms underlying the enhancement of antigen immunogenicity by starch nanoparticles (NPL) delivery systems in H292 epithelial cells, as well as the NPL’s immunomodulatory effect. We observed that NPL had no intrinsic immunomodulatory effect but enhanced the immunogenicity of an E. coli lysate (Ag) merely by increasing its intracellular delivery. Moreover, we demonstrated the importance of the NPL density on their efficiency by comparing reticulated (NPL) and non-reticulated particles (NPL·NR). These results show that an efficient delivery system is sufficient to induce a mucosal immune response without the use of immunomodulators.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2024-01-12T00:58:07Z
2024-01-25T08:53:36Z