Title :

Post-Transplantation Early Blood Transfusion and Kidney Allograft Outcomes: A Single-Center Observational Study.

Author(s) :

Khedjat, Kahina [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Lenain, Remi [Auteur]
MethodS in Patients-centered outcomes and HEalth ResEarch [SPHERE]
Hamroun, Aghiles [Auteur]
Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 [RID-AGE]
Centre de recherche en épidémiologie et santé des populations [CESP]
Baes, Dulciane [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Top, Isabelle [Auteur]
Institut d'Immunologie [CHRU Lille]
Labalette, Myriam [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Lopez, Benjamin [Auteur]
van Triempont, Marine [Auteur]
Provôt, François [Auteur]
Service de Néphrologie et Transplantation rénale [CHRU-lille]
Frimat, Marie [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Gibier, Jean-Baptiste [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Hazzan, Marc [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Maanaoui, Mehdi [Auteur]
Institut Pasteur de Lille
Recherche translationnelle sur le diabète - U 1190 [RTD]

Journal title :

Transplant International

Abbreviated title :

Transpl Int

Volume number :

35

Pages :

10279

Publication date :

2022-04-06

ISSN :

1432-2277

English keyword(s) :

kidney transplantation
allograft failure
graft loss
donor specific antibody
blood transfusion

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

The association between blood transfusion and the occurrence of de novo HLA donor specific antibodies (DSA) after kidney transplantation remains controversial. In this single-center observational study, we examined the ...
Show more >The association between blood transfusion and the occurrence of de novo HLA donor specific antibodies (DSA) after kidney transplantation remains controversial. In this single-center observational study, we examined the association between early blood transfusion, i.e. before 1-month post-transplantation, and the risk of DSA occurrence, using Luminex based-methods. In total, 1,424 patients with a minimum of 1-month follow-up were evaluated between January 2007 and December 2018. During a median time of follow-up of 4.52 years, we observed 258 recipients who had at least one blood transfusion during the first month post-transplantation. At baseline, recipients in the transfused group were significant older, more sensitized against HLA class I and class II antibodies and had a higher 1-month serum creatinine. Cox proportional hazards regression analyses did not show any significant association between blood transfusion and the risk of de novo DSA occurrence (1.35 [0.86–2.11], p = 0.19), the risk of rejection (HR = 1.33 [0.94–1.89], p = 0.11), or the risk of graft loss (HR = 1.04 [0.73–1.50], p = 0.82). These data suggest then that blood transfusion may not be limited when required in the early phase of transplantation, and may not impact long-term outcomes.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement (RID-AGE) - U1167
• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
• Lille Neurosciences & Cognition (LilNCog) - U 1172
• Recherche translationnelle sur le diabète (RTD) - U1190

Submission date :

2024-01-12T01:50:29Z
2024-03-27T10:34:29Z