Title :

Blood biomarkers recommended for diagnosing and monitoring IgG4-related disease. Considerations from the ERN ReCONNET and collaborating partners.

Author(s) :

Iaccarino, L. [Auteur]
Talarico, R. [Auteur]
Bozzalla-Cassione, E. [Auteur]
Burmester, G. R. [Auteur]
Culver, E. L. [Auteur]
Doria, A. [Auteur]
Ebbo, Mikael [Auteur]
Hôpital de la Timone [CHU - APHM] [TIMONE]
Van Hagen, P. M. [Auteur]
Hachulla, Eric [Auteur]
Centre National de Référence des Maladies Auto-Immunes Systémiques Rares du Nord et Nord-Ouest de France [CeRAINO]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Van Laar, J. A. M. [Auteur]
Lanzillotta, M. [Auteur]
Martinez-Valle, F. [Auteur]
Montecucco, C. [Auteur]
Monti, S. [Auteur]
Nalli, C. [Auteur]
Schleinitz, Nicolas [Auteur]
Hôpital de la Timone [CHU - APHM] [TIMONE]
Tincani, A. [Auteur]
Della Torre, E. [Auteur]
Alexander, T. [Auteur]

Journal title :

Clin Exp Rheumatol

Abbreviated title :

Clin Exp Rheumatol

Volume number :

134

Pages :

71-80

Publication date :

2022-03-05

ISSN :

0392-856X

English keyword(s) :

fibrosis
prognosis
prediction
IgG4
IgG4-related disease
ERN
biomarker

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Immunoglobulin G4 (IgG4)-related disease (IgG4-RD) is a chronic, clinically heterogenous fibroinflammatory condition, characterised by an accumulation of IgG4 secreting plasma cells in affected tissues and associated with ...
Show more >Immunoglobulin G4 (IgG4)-related disease (IgG4-RD) is a chronic, clinically heterogenous fibroinflammatory condition, characterised by an accumulation of IgG4 secreting plasma cells in affected tissues and associated with increased serum IgG4 concentrations. Despite a growing recognition of the disease among clinicians from different specialties worldwide, its indolent nature, lack of a single diagnostic test and ability to mimic other malignant, infective and inflammatory conditions, makes the diagnosis challenging. As treatment options evolve, biomarkers correlating with disease activity, predicting prognosis and response to treatment are deemed required. A multidisciplinary panel of experts from the European Reference Network for Rare and Complex Connective tissue diseases (ERN ReCONNET) and affiliated international partners have performed a narrative literature search and reviewed the current evidence of biomarkers in IgG4-RD, including immunoglobulins, cytokines, chemokines and other soluble immune mediators, and cellular components of the immune system. The aim of this paper is to provide useful information for clinicians as to the utility of biomarkers for diagnosing and monitoring IgG4-RD in clinical routine and sets out recommendations for clinical decision making.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2024-01-12T02:09:04Z
2024-03-22T07:10:53Z