Title :

The Burden of NAFLD in Type 2 Diabetic Subjects from the General Population: a Nationwide Population-Based Follow-Up Study (NASHCO).

Author(s) :

Nabi, Oumarou [Auteur]
Institut Pierre Louis d'Epidémiologie et de Santé Publique [iPLESP]
Boursier, Jerome [Auteur]
Hémodynamique, Interaction Fibrose et Invasivité tumorales Hépatiques [HIFIH]
Lapidus, Nathanaël [Auteur]
Institut Pierre Louis d'Epidémiologie et de Santé Publique [iPLESP]
Mathurin, Philippe [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
De Ledinghen, Victor [Auteur]
Centre Hospitalier Universitaire de Bordeaux [CHU Bordeaux]
Petit, Jean-Michel [Auteur]
CHU Dijon
Goldberg, Marcel [Auteur]
Cohortes épidémiologiques en population [CONSTANCES]
Zins, Marie [Auteur]
Cohortes épidémiologiques en population [CONSTANCES]
Lacombe, Karine [Auteur]
Institut Pierre Louis d'Epidémiologie et de Santé Publique [iPLESP]
Serfaty, Lawrence [Auteur]
Centre de Recherche Saint-Antoine [CRSA]

Journal title :

Liver International

Abbreviated title :

Liver Int

Volume number :

42

Pages :

595-606

Publication date :

2022-01-27

ISSN :

1478-3231

English keyword(s) :

advanced fibrosis
cardiovascular disease
chronic kidney disease
extrahepatic malignancy mortality
fatty liver index
Forns index
obesity
type 2 diabetes

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Background The epidemiology and natural history of non-alcoholic fatty liver disease (NAFLD) in diabetes have been mainly investigated in the hospital setting. The goal of this study was to evaluate the characteristics ...
Show more >Background The epidemiology and natural history of non-alcoholic fatty liver disease (NAFLD) in diabetes have been mainly investigated in the hospital setting. The goal of this study was to evaluate the characteristics of NAFLD and its impact on morbidity and mortality in type 2 diabetic subjects in a community setting. Method This study included 199 341 participants in the nationwide Constances cohort. After patients with excessive alcohol consumption, viral hepatitis or other causes of liver disease were excluded, 164 285 were analysed and 8386 (5.3%) were considered to have type 2 diabetes. The non-invasive diagnosis of NAFLD and advanced fibrosis was made using a combination of the fatty liver index and Forns index. Median follow-up was 2.5 years. Results Diabetes increased the risk of NAFLD by sixfold (adjusted OR 6.05, 95% CI 5.68-6.45) and the risk of advanced fibrosis by 3.76-fold (aOR 3.76, 95% CI 2.87-4.91) in NAFLD subjects. After controlling for confounders, the presence of NAFLD in diabetic subjects was associated with an increased risk of severe liver-related events (aHR 2.53, 95% CI 1.36-4.69), cardiovascular disease (CVD, aHR 2.71, 95% CI 1.72-4.26) and overall mortality (aHR 2.91, 95% CI 1.53-5.53). The risk of hepatic and extrahepatic complications in diabetic subjects with NAFLD significantly increased with the severity of fibrosis (P < .05). Conclusion This prospective, longitudinal study in a large community-based cohort provides real-world evidence of the risk for NAFLD and advanced fibrosis in diabetes, and its impact on liver disease progression, diabetes-related complications such as CVD, and overall mortality. These data could be used to estimate real clinical and economic burden of NAFLD in diabetic subjects.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2024-01-12T02:26:23Z
2024-03-13T10:18:01Z