Titre :

Does control of glycemia regulate immunological parameters in insulin-treated persons with type 1 diabetes?

Auteur(s) :

Nekoua, Magloire Pandoua [Auteur]
Laboratoire de virologie - ULR 3610
Fachinan, Rufine [Auteur]
Institut des Sciences Biomédicales Appliquées [ISBA]
Fagninou, Adnette [Auteur]
Institut des Sciences Biomédicales Appliquées [ISBA]
Alidjinou, Enagnon Kazali [Auteur]
Laboratoire de virologie - ULR 3610
Moutairou, Kabirou [Auteur]
Institut des Sciences Biomédicales Appliquées [ISBA]
Hober, Didier [Auteur]
Laboratoire de virologie - ULR 3610
Yessoufou, Akadiri [Auteur]
Institut des Sciences Biomédicales Appliquées [ISBA]

Titre de la revue :

Diabetes Research and Clinical Practice

Nom court de la revue :

Diabetes Res. Clin. Pract.

Numéro :

157

Pagination :

107868

Date de publication :

2019-10-05

ISSN :

1872-8227

Mot(s)-clé(s) en anglais :

Type 1 diabetes
Glycemic control
Insulin
Immune cells
Cytokines

Discipline(s) HAL :

Sciences du Vivant [q-bio]/Médecine humaine et pathologie

Résumé en anglais : [en]

Aims We investigated the relationships between control of glycemia and the frequencies of immune cell subpopulations and also the profile of circulating T cell cytokines in insulin-treated persons with type 1 diabetes ...
Lire la suite >Aims We investigated the relationships between control of glycemia and the frequencies of immune cell subpopulations and also the profile of circulating T cell cytokines in insulin-treated persons with type 1 diabetes (T1D). Methods Clinical data and blood samples were collected from two groups of persons with T1D exhibiting either adequate (AGC) or inadequate glycemic control (IGC), as well as from individuals without diabetes considered as a control group. Serum cytokine levels and immune cell subpopulation frequencies were determined. Results Irrespective of their capacity to control glycemia, the percentages of effector CD4+ T-cells and CD19+ B-cells were higher in persons with T1D than in controls, whilst monocytes were significantly more frequent in those with IGC than in controls. The overall frequencies of CD4+ T-cells, CD8+ T-cells and Foxp3+CD4+CD25+ regulatory T-cells did not differ between the three groups. The serum levels of IL-2 and IFN-γ were lower in both groups with T1D compared to controls, whilst the level of IL-4 did not differ. The level of IL-10 was significantly lower in those with AGC compared to controls. Conclusion Our study shows that insulin treatment is associated with a Th2-biased systemic immune phenotype in persons with T1D, reflected by a high proportion of effector CD4+ T cells and CD19+ B cells and a down-regulation of Th1-type serum cytokines.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
CHU Lille

Collections :

• Laboratoire de virologie - ULR 3610

Date de dépôt :

2024-01-17T22:31:05Z
2024-02-13T10:43:05Z