Title :

Dramatic increase in incidence of ulcerative colitis and crohn''s disease (1988-2011): a population-based study of french adolescents

Author(s) :

Ghione, Silvia [Auteur]
Sarter, Helene [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Fumery, Mathurin [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Armengol-Debeir, Laura [Auteur]
Savoye, Guillaume [Auteur]
Ley, Delphine [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Spyckerelle, Claire [Auteur]
Hôpital Saint Vincent de Paul de Lille
Pariente, Benjamin [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Peyrin-Biroulet, Laurent [Auteur]
Turck, Dominique [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Gower, Corinne [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]

Journal title :

The American Journal of Gastroenterology

Abbreviated title :

Am. J. Gastroenterol.

Volume number :

113

Pages :

265-272

Publication date :

2018-02

ISSN :

0002-9270

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Few data are available to describe the changes in incidence of pediatric-onset inflammatory bowel disease (IBD). The aim of this study was to describe changes in incidence and phenotypic presentation of pediatric-onset IBD ...
Show more >Few data are available to describe the changes in incidence of pediatric-onset inflammatory bowel disease (IBD). The aim of this study was to describe changes in incidence and phenotypic presentation of pediatric-onset IBD in northern France during a 24-year period. Pediatric-onset IBD (<17 years) was issued from a population-based IBD study in France between 1988 and 2011. Age groups and digestive location were defined according to the Paris classification. 1,350 incident cases were recorded (8.3% of all IBD) including 990 Crohn's disease (CD), 326 ulcerative colitis (UC) and 34 IBD unclassified (IBDU). Median age at diagnosis was similar in CD (14.4 years (Q1=11.8-Q3=16.0)) and UC (14.0 years (11.0-16.0)) and did not change over time. There were significantly more males with CD (females/males=0.82) than UC (females/males=1.25) (P=0.0042). Median time between onset of symptoms and IBD diagnosis was consistently 3 months (1-6). Mean incidence was 4.4/10555 In this population-based study, CD and UC incidences increased dramatically in adolescents across a 24-year span, suggesting that one or more strong environmental factors may predispose this population to IBD.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
Inserm
Université de Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2024-01-30T10:26:31Z
2024-03-07T12:34:17Z