Titre :

Natural history of recurrent alcohol-related cirrhosis after liver transplantation: fast and furious

Auteur(s) :

Erard-Poinsot, Domitille [Auteur]
Université Claude Bernard Lyon 1 [UCBL]
Dharancy, Sebastien [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Hilleret, Marie-Noelle [Auteur]
Université Grenoble Alpes [UGA]
Faure, Stephanie [Auteur]
Université de Montpellier [UM]
Lamblin, Geraldine [Auteur]
CHU Clermont-Ferrand
Chambon-Augoyard, Christine [Auteur]
Université Claude Bernard Lyon 1 [UCBL]
Donnadieu-Rigole, Helene [Auteur]
Université de Montpellier [UM]
Lassailly, Guillaume [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Boillot, Olivier [Auteur]
Université Claude Bernard Lyon 1 [UCBL]
Ursic-Bedoya, Jose [Auteur]
Université de Montpellier [UM]
Guillaud, Olivier [Auteur]
Université Claude Bernard Lyon 1 [UCBL]
Leroy, Vincent [Auteur]
Université Grenoble Alpes [2016-2019] [UGA [2016-2019]]
Pageaux, Georges-Philippe [Auteur]
Université de Montpellier [UM]
Dumortier, Jerome [Auteur]
Université Claude Bernard Lyon 1 [UCBL]

Titre de la revue :

Liver Transplantation

Nom court de la revue :

Liver Transpl.

Numéro :

26

Pagination :

25-33

Date de publication :

2020-01

ISSN :

1527-6473

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Alcohol-related liver disease (ALD) is one of the main indications for liver transplantation (LT). Severe alcohol relapse can rapidly lead to recurrent alcohol-related cirrhosis (RAC) for the graft. The aim of this study ...
Lire la suite >Alcohol-related liver disease (ALD) is one of the main indications for liver transplantation (LT). Severe alcohol relapse can rapidly lead to recurrent alcohol-related cirrhosis (RAC) for the graft. The aim of this study was to describe the natural history of RAC and the overall survival after LT and after an RAC diagnosis. From 1992 to 2012, 812 patients underwent primary LT for ALD in 5 French transplant centers. All patients with severe alcohol relapse and an RAC diagnosis on the graft were included. The diagnosis of cirrhosis was based on the analysis of liver biopsy or on the association of clinical, biological, radiological, and/or endoscopic features of cirrhosis. RAC was diagnosed in 57/162 patients (35.2%) with severe alcohol relapse, and 31 (54.4%) of those patients had at least 1 episode of liver decompensation. The main types of decompensation were ascites (70.9%), jaundice (58.0%), and hepatic encephalopathy (9.6%). The cumulative probability of decompensation was 23.8% at 5 years, 50.1% at 10 years, and 69.9% at 15 years after LT. During the follow-up, 36 (63.2%) patients died, the main cause of death being liver failure (61.1%). After diagnosis of cirrhosis, the survival rate was 66.3% at 1 year, 37.8% at 5 years, and 20.6% at 10 years. In conclusion, RAC is associated with a high risk of liver decompensation and a poor prognosis. Prevention of severe alcohol relapse after LT is a major goal to improve patient survival.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

CHU Lille
Inserm
Université de Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Date de dépôt :

2024-01-30T10:27:13Z
2024-03-28T12:43:43Z