Title :

Systemic lupus erythematosus in native sub-saharan africans: a systematic review and meta-analysis

Author(s) :

Essouma, Mickael [Auteur]
Nkeck, Jan Rene [Auteur]
Endomba, Francky Teddy [Auteur]
Bigna, Jean Joel [Auteur]
Singwe-Ngandeu, Madeleine [Auteur]
Hachulla, Eric [Auteur]

Journal title :

Journal of autoimmunity

Abbreviated title :

J. Autoimmun.

Pages :

102348

Publication date :

2019-10-23

ISSN :

1095-9157

English keyword(s) :

Systemic lupus erythematous
Native sub-Saharan Africans

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

The prevalence and phenotype of systemic lupus erythematosus (SLE) have not been thoroughly investigated in Native sub-Saharan Africans despite knowledge that the highest burden of SLE occurs in people with an African ...
Show more >The prevalence and phenotype of systemic lupus erythematosus (SLE) have not been thoroughly investigated in Native sub-Saharan Africans despite knowledge that the highest burden of SLE occurs in people with an African trait. Through this systematic review of literature and meta-analysis, we wished to fill this gap. PubMed, EMBASE, Web of Science, African Journals Online, and Global Index Medicus as well as references of retrieved papers were searched to select studies addressing SLE in Native sub-Saharan Africans and published between January 1, 2008 and October 7, 2018. The prevalence of SLE and its characteristics were pooled through narrative review and random-effects model. Heterogeneity (I22 Out of 1502 papers, 15 hospital-based studies were included. The pooled prevalence of SLE among 28,575 participants was 1.7% (0.8-2.9), with substantial heterogeneity between studies (I2 Over the last 30 years, SLE was not rare among Native sub-Saharan Africans and its featured characteristics were earlier onset, female predominance, and high seropositivity for extractable nuclear antigen autoantibodies. Corticosteroids and antimalarials were the standard treatments. The mortality rate was high. Population prevalence and incidence as well as full description of SLE characteristics in Native sub-Saharan Africans are needed.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
Inserm
Université de Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2024-01-30T10:27:30Z