Titre :

Evaluation and Modelling of the Performance of an Automated SARS-CoV-2 Antigen Assay According to Sample Type, Target Population and Epidemic Trends

Auteur(s) :

Yin, Nicolas [Auteur]
Université libre de Bruxelles [ULB]
Debuysschere, Cyril [Auteur]
Laboratoire de Virologie - ULR 3610 [Laboratoire de Virologie]
Daubie, Valery [Auteur]
Université libre de Bruxelles [ULB]
Hildebrand, Marc [Auteur]
Université libre de Bruxelles [ULB]
Martin, Charlotte [Auteur]

Curac, Sonja [Auteur]
Ponthieux, Fanny [Auteur]
Université libre de Bruxelles [ULB]
Payen, Marie-Christine [Auteur]
Université libre de Bruxelles [ULB]
Vandenberg, Olivier [Auteur]
Université libre de Bruxelles [ULB]
Hallin, Marie [Auteur]
Université libre de Bruxelles [ULB]

Titre de la revue :

Diagnostics

Nom court de la revue :

Diagnostics

Numéro :

12

Pagination :

447

Date de publication :

2023-05-02

ISSN :

2075-4418

Mot(s)-clé(s) en anglais :

SARS-CoV-2
COVID-19
model
diagnostic
test
assay

Discipline(s) HAL :

Sciences du Vivant [q-bio]/Médecine humaine et pathologie

Résumé en anglais : [en]

The Lumipulse® G SARS-CoV-2 Ag assay performance was evaluated on prospectively collected saliva and nasopharyngeal swabs (NPS) of recently ill in- and outpatients and according to the estimated viral load. Performances ...
Lire la suite >The Lumipulse® G SARS-CoV-2 Ag assay performance was evaluated on prospectively collected saliva and nasopharyngeal swabs (NPS) of recently ill in- and outpatients and according to the estimated viral load. Performances were calculated using RT-PCR positive NPS from patients with symptoms ≤ 7 days and RT-PCR negative NPS as gold standard. In addition, non-selected positive NPS were analyzed to assess the performances on various viral loads. This assay yielded a sensitivity of 93.1% on NPS and 71.4% on saliva for recently ill patients. For NPS with a viral load > 103 RNA copies/mL, sensitivity was 96.4%. A model established on our daily routine showed fluctuations of the performances depending on the epidemic trends but an overall good negative predictive value. Lumipulse® G SARS-CoV-2 assay yielded good performance for an automated antigen detection assay on NPS. Using it for the detection of recently ill patients or to screen high-risk patients could be an interesting alternative to the more expensive RT-PCR.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
CHU Lille

Collections :

• Laboratoire de virologie - ULR 3610

Date de dépôt :

2024-02-02T22:05:33Z
2024-02-13T09:01:29Z