Titre :

Association between public health policies on alcohol and worldwide cancer, liver disease and cardiovascular disease outcomes.

Auteur(s) :

Díaz, Luis Antonio [Auteur]
Pontificia Universidad Católica de Chile [UC]
Fuentes-López, Eduardo [Auteur]
Pontificia Universidad Católica de Chile [UC]
Idalsoaga, Francisco [Auteur]
Pontificia Universidad Católica de Chile [UC]
Ayares, Gustavo [Auteur]
Pontificia Universidad Católica de Chile [UC]
Corsi, Oscar [Auteur]
Pontificia Universidad Católica de Chile [UC]
Arnold, Jorge [Auteur]
Pontificia Universidad Católica de Chile [UC]
Cannistra, Macarena [Auteur]
Pontificia Universidad Católica de Chile [UC]
Vio, Danae [Auteur]
Pontificia Universidad Católica de Chile [UC]
Márquez-Lomas, Andrea [Auteur]
Ramirez-Cadiz, Carolina [Auteur]
University of Western Ontario [UWO]
Medel, María Paz [Auteur]
Pontificia Universidad Católica de Chile [UC]
Hernandez-Tejero, María [Auteur]
Mayo Clinic [Rochester]
Ferreccio, Catterina [Auteur]
Pontificia Universidad Católica de Chile [UC]
Lazo, Mariana [Auteur]
Drexel University
Roblero, Juan Pablo [Auteur]
Universidad de Chile = University of Chile [Santiago] [UCHILE]
Cotter, Thomas G. [Auteur]
University of Texas Southwestern Medical Center [Dallas]
Kulkarni, Anand V. [Auteur]
University of Hyderabad
Kim, Won [Auteur]
Seoul National University Hospital
Brahmania, Mayur [Auteur]
University of Calgary
Louvet, Alexandre [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Tapper, Elliot B. [Auteur]
University of Michigan [Ann Arbor]
Dunn, Winston [Auteur]
University of Kansas [Kansas City]
Simonetto, Douglas [Auteur]
Mayo Clinic [Rochester]
Shah, Vijay H. [Auteur]
Mayo Clinic [Rochester]
Kamath, Patrick S. [Auteur]
Mayo Clinic [Rochester]
Lazarus, Jeffrey V. [Auteur]
Instituto de Salud Global - Institute For Global Health [Barcelona] [ISGlobal]
Singal, Ashwani K. [Auteur]
University of Louisville School of Medicine [Louisville]
Bataller, Ramon [Auteur]

Arrese, Marco [Auteur]
Pontificia Universidad Católica de Chile [UC]
Arab, Juan Pablo [Auteur]
Pontificia Universidad Católica de Chile [UC]

Titre de la revue :

Journal of Hepatology

Nom court de la revue :

J Hepatol

Date de publication :

2023-11-24

ISSN :

1600-0641

Résumé en anglais : [en]

Background & Aims The long-term impact of alcohol-related public health policies (PHPs) on disease burden is unclear. We aimed to assess the association between alcohol-related PHPs and alcohol-related health consequenc ...
Lire la suite >Background & Aims The long-term impact of alcohol-related public health policies (PHPs) on disease burden is unclear. We aimed to assess the association between alcohol-related PHPs and alcohol-related health consequences. Methods We conducted an ecological multi-national study including 169 countries. We collected data on alcohol-related PHPs from the WHO Global Information System of Alcohol and Health 2010. Data on alcohol-related health consequences between 2010–2019 were obtained from the Global Burden of Disease database. We classified PHPs into five items, including criteria for low, moderate, and strong PHP establishment. We estimated an alcohol preparedness index (API) using multiple correspondence analysis (0 lowest and 100 highest establishment). We estimated an incidence rate ratio (IRR) for outcomes according to API using adjusted multilevel generalized linear models with a Poisson family distribution. Results The median API in the 169 countries was 54 [IQR 34.9–76.8]. The API was inversely associated with alcohol use disorder (AUD) prevalence (IRR 0.13; 95% CI 0.03–0.60; p = 0.010), alcohol-associated liver disease (ALD) mortality (IRR 0.14; 95% CI 0.03–0.79; p = 0.025), mortality due to neoplasms (IRR 0.09; 95% CI 0.02–0.40; p = 0.002), alcohol-attributable hepatocellular carcinoma (HCC) (IRR 0.13; 95% CI 0.02–0.65; p = 0.014), and cardiovascular diseases (IRR 0.09; 95% CI 0.02–0.41; p = 0.002). The highest associations were observed in the Americas, Africa, and Europe. These associations became stronger over time, and AUD prevalence was significantly lower after 2 years, while ALD mortality and alcohol-attributable HCC incidence decreased after 4 and 8 years from baseline API assessment, respectively (p <0.05). Conclusions The API is a valuable instrument to quantify the robustness of alcohol-related PHP establishment. Lower AUD prevalence and lower mortality related to ALD, neoplasms, alcohol-attributable HCC, and cardiovascular diseases were observed in countries with a higher API. Our results encourage the development and strengthening of alcohol-related policies worldwide. Impact and implications We first developed an alcohol preparedness index, an instrument to assess the existence of alcohol-related public policies for each country. We then evaluated the long-term association of the country's alcohol preparedness index in 2010 with the burden of chronic liver disease, hepatocellular carcinoma, other neoplasms, and cardiovascular disease. The strengthening of alcohol-related public health policies could impact long-term mortality rates from cardiovascular disease, neoplasms, and liver disease. These conditions are the main contributors to the global burden of disease related to alcohol use. Over time, this association has not only persisted but also grown stronger. Our results expand the preliminary evidence regarding the importance of public health policies in controlling alcohol-related health consequences.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Date de dépôt :

2024-02-03T22:12:09Z
2024-03-14T12:27:14Z